Objective    To study the distribution of HBV genotypes in HBV infection-associated hepatocellular carcinoma (HCC) and in different phases of natural chronic HBV infection history.     Methods    HBV genotypes in 46 patients with HBV infection-associated HCC and 90 patients with a natural chronic HBV infection history at different phases in the Northern Guangxi Zhuang Autonomous Region were identified by real-time fluorescence quantitative PCR. Laboratory findings and pathological data were obtained from medical records of the patients.     Results    Genotypes B

C

and non-A and B accounted for 77.8%

18.9%

and 3.3%

respectively

in patients with chronic HBV infection. Genotypes B and C accounted for 78.3% and 21.7% in HCC patients. No significant difference was observed in distribution of HBV genotypes among the patients with HBV infection

HCC

and chronic HBV infection at different phases (P0.05). A significant difference was found in HBV-DNA between genotypes B and C （P0.01）. The ALT

AST

TBIL

ALB

and age levels were significantly higher in HCC patients than in those with chronic HBV infection at different phases（P0.05）.     Conclusion    Genotype B is dominant in patients with chronic HBV infection and HBV infection-associated HCC in the Northern Guangxi Zhuang Autonomous Region with no difference in distribution of HBV genotypes in patients with HCC and a natural chronic HBV infection history at different phases. The HBV-DNA level is higher in genotype C than in other HBV genotypes.