Upregulation of PPARγ and PCNA in oral squamous cell carcinoma tissue and its clinical significance

陈彦平; 杨凯成; 梁玉林; 杨会钗; 王小玲

您当前的位置：

首页 >

文章列表页 >

Upregulation of PPARγ and PCNA in oral squamous cell carcinoma tissue and its clinical significance

更新时间：2026-01-09

- Upregulation of PPARγ and PCNA in oral squamous cell carcinoma tissue and its clinical significance
- Journal of Army Medical University Vol. 33, Issue 16, Pages: 1718-1721(2011)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.23;R739.85
- Published：2011
- 稿件说明：
移动端阅览
陈彦平,杨凯成,梁玉林,杨会钗,王小玲.PPARγ和PCNA在口腔鳞癌组织的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2011,33(16):1718-1721.

　Chen Yanping,Yang Kaicheng,Liang Yulin,Yang Huichai,Wang Xiaoling.Upregulation of PPARγ and PCNA in oral squamous cell carcinoma tissue and its clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(16):1718-1721.
陈彦平,杨凯成,梁玉林,杨会钗,王小玲.PPARγ和PCNA在口腔鳞癌组织的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2011,33(16):1718-1721. DOI：

　Chen Yanping,Yang Kaicheng,Liang Yulin,Yang Huichai,Wang Xiaoling.Upregulation of PPARγ and PCNA in oral squamous cell carcinoma tissue and its clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(16):1718-1721. DOI：

摘要

目的探讨过氧化物酶体增殖物激活受体（PPARγ）与增殖细胞核抗原（proliferating cell nuclear antigen

PCNA）在口腔鳞癌中（oral squamous-cell carcinoma，OSCC）的表达及其生物学意义。方法采用免疫组织化学和流式细胞术检测50例口腔鳞状细胞癌、癌旁黏膜（距瘤缘2 cm）和切缘正常黏膜（距瘤缘≥5 cm，镜下未见癌浸润）标本中PPARγ和PCNA的表达。结果 PPARγ在癌组织中的阳性表达率为68.0%（34/50），高于癌旁组织（26.0%，13/50）和正常黏膜组织（2.0%，1/50）（P0.05）；PCNA在癌组织中的阳性表达率为72.0%（36/50），高于癌旁组织（26.0%，13/50）和正常黏膜组织（4.0%，2/50）（P0.05）。流式细胞术检测PPARγ在鳞癌组织中的表达为（396.56±33.39），明显高于癌旁组织（333.36±15.93）及正常口腔黏膜组织（289.28±13.80）（P0.05）。PCNA在鳞癌组织中的表达为（543.11±41.55），明显高于癌旁组织（456.97±23.86）和正常口腔黏膜组织（409.40±40.07）（P0.05）。PPARγ和PCNA的表达与细胞分化程度、淋巴结转移均有相关性（PPARγ，r分别为0.497、0.392，P0.05；PCNA， r分别为0.324、0.561，P0.05），且二者在口腔鳞癌中的表达呈正相关。结论口腔鳞癌组织中PPARγ和PCNA的表达均升高，可能与口腔鳞癌的发生、发展相关。

Abstract

Objective To investigate the expression of peroxisome proliferator-activated receptor γ (PPARγ) and proliferating cell nuclear antigen (PCNA) in oral squamous cell carcinoma (OSCC) tissue and its clinical significance. Methods SP immunohistochemical staining and flow cytometry were used to evaluate the expression levels of PPARγ and PCNA in the OSCC tissues

paracancerous mucosae (2 cm from the tumor margin)

and normal mucosae (≥5 cm from the tumor margin

no microscopic cancer invasion) from 50 cases. Results The positive expression rate of PPARγ in OSCC tissues (68.0%

34/50) was significantly higher than those in paracancerous mucosae (26.0%

13/50) and normal mucosae (2.0%

1/50) (P0.05). The positive expression rate of PCNA in OSCC tissues (72.0%

36/50) was significantly higher than those in paracancerous mucosae (26.0%

13/50) and normal mucosae (4.0%

2/50) (P0.05). The flow cytometry result showed that the expression of PPARγ in OSCC tissues (396.56±33.39) was significantly higher than those in paracancerous mucosae (333.36±15.93) and normal mucosae (289.28±13.80) (P0.01) and that the expression of PCNA in OSCC tissues (543.11±41.55) was significantly higher than those in paracancerous mucosae (456.97±23.86) and normal mucosae (409.40±40.07) (P0.01). The high expression of PPARγ and PCNA was positively correlated with poor differentiation and lymph node metastasis of OSCC (the correlation coefficients of PPARγ were 0.497 and 0.392

P0.05; the correlation coefficients of PCNA were 0.324 and 0.561

P0.05). There was a positive correlation between PPARγ expression and PCNA expression. Conclusion The expression of PPARγ and PCNA is increased in OSCC tissues

indicating that PPARγ and PCNA may be involved in the carcinogenesis and development of OSCC.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of serum containing modified turtle shell decoction on proliferation, cell cycle and apoptosis of hepatic stellate cell line T6

Expression and clinical significance of miRNA-205 in esophageal squamous cell carcinoma

Effect of Jumonji domain-containing protein 2B on biological behaviors in human cutaneous squamous cell carcinoma A431 cells

Correlation between expression of nucleostemin and proliferating cell nuclear antigen in colorectal cancer tissues and serum folic acid concentrations

Relationship of NF-κB expression with vascular proliferation in basilar artery of subarachnoid hemorrhage rabbits

Related Author

粟永萍

汪国建

闫国和

张荣华

贺付成

董翠翠

孟伟伟

吕彦萌

Related Institution

No data

⁰