Correlation between polymorphisms of DRB1, -DQA1, and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China

李素芝; 蒋亚建; 谢本维; 曾晓华; 杜翔; 李世学; 次罗; 小平措; 尼珍; 贡布; 边马措; 蒋业贵

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Correlation between polymorphisms of DRB1, -DQA1, and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China

更新时间：2026-01-09

- Correlation between polymorphisms of DRB1, -DQA1, and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China
- Journal of Army Medical University Vol. 33, Issue 12, Pages: 1254-1257(2011)
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  CLC： R521.02;R195.4;R394
- Published：2011
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李素芝,蒋亚建,谢本维,曾晓华,杜翔,李世学,次罗,小平措,尼珍,贡布,边马措,蒋业贵.中国藏族人群HLA-DRB1、-DQA1、-DQB1等位基因多态性与肺结核易感性的关联性研究[J].陆军军医大学学报(原第三军医大学学报),2011,33(12):1254-1257.

　Li Suzhi,Jiang Yajian,Xie Benwei,Zeng Xiaohua,Du Xiang,Li Shixue,Ci Luo,Xiao Pingcuo,Ni Zhen,Gong Bu,Bian Macuo,Jiang Yegui.Correlation between polymorphisms of DRB1, -DQA1, and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(12):1254-1257.
李素芝,蒋亚建,谢本维,曾晓华,杜翔,李世学,次罗,小平措,尼珍,贡布,边马措,蒋业贵.中国藏族人群HLA-DRB1、-DQA1、-DQB1等位基因多态性与肺结核易感性的关联性研究[J].陆军军医大学学报(原第三军医大学学报),2011,33(12):1254-1257. DOI：

　Li Suzhi,Jiang Yajian,Xie Benwei,Zeng Xiaohua,Du Xiang,Li Shixue,Ci Luo,Xiao Pingcuo,Ni Zhen,Gong Bu,Bian Macuo,Jiang Yegui.Correlation between polymorphisms of DRB1, -DQA1, and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(12):1254-1257. DOI：

摘要

目的探讨HLA-DRB1、-DQA1和-DQB1等位基因多态性与中国藏族人群肺结核易感性之间的关系。方法采用聚合酶链反应/序列特异性引物（PCR/SSP）技术对176例中国西藏地区藏族肺结核患者和189例该地区藏族健康人群的HLA-DRB1、-DQA1和-DQB1等位基因多态性进行分析。结果 HLA-DRB1*0901、-DQA1*0101和-DQB1*0301在肺结核组的等位基因频率明显高于健康对照组，2组相比差异具有统计学意义（17.33% vs 7.94%，χ

=17.185，P=0.000，OR=2.811；25.85% vs 13.76%，χ

=22.382，P=0.000，OR=2.821；35.51% vs 19.58%，χ

=37.329，P=0.000，OR=3.809）。HLA-DRB1*1301/1302、-DQA1*0501在肺结核组的等位基因频率明显低于健康对照组，2组相比差异具有统计学意义（0.85% vs 6.08%，χ

=15.085，P=0.000，OR=0.125；14.49% vs 26.72%，χ

=22.44，P=0.000，OR=0.355）。结论 HLA-DRB1*0901、-DQA1*0101和-DQB1*0301与肺结核的易感性密切相关，可能是肺结核的易感基因。HLA-DQA1*0301与肺结核的保护性密切相关，可能为肺结核的保护基因。

Abstract

Objective To study the correlation between polymorphisms of HLA-DRB1

-DQA1 and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China. Methods HLA-DRB1

-DQA1 and -DQB1 alleles in 176 patients with pulmonary tuberculosis and 189 normal controls were analyzed using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique. Results The frequencies of HLA-DRB1*0901

-DQA1*0101 and -DQB1*0301 alleles were significantly higher in pulmonary tuberculosis patients than in normal controls (17.33% vs 7.94%

25.85% vs 13.76%

35.51% vs 19.58%

Chi-square=17.185，P=0.000，OR=2.811；Chi-square=22.382，P=0.000，OR=2.821；Chi-square=37.329，P=0.000，OR=3.809)

while the frequencies of HLA-DRB1*1301/1302 and -DQA1*0501 alleles were significantly lower in pulmonary tuberculosis patients than in normal controls (0.85% vs 6.08%

14.49% vs 26.72%

Chi-square=15.085，P=0.000，OR=0.125；Chi-square=22.44，P=0.000，OR=0.355). Conclusion HLA-DRB1*0901

-DQA1*0101 and -DQB1*0301 alleles are closely related with the susceptibility to pulmonary tuberculosis and may be the susceptible genes against pulmonary tuberculosis. HLA-DRB1*1301/1302 and -DQA1*0501 alleles are closely related with the protection of pulmonary tuberculosis and may be the protective genes against pulmonary tuberculosis.

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