Expression of Claudin-3 in gastric adenocarcinoma tissue and its relation with prognosis

张真真; 张声; 余英豪; 陈虹; 陈余朋

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Expression of Claudin-3 in gastric adenocarcinoma tissue and its relation with prognosis

更新时间：2026-01-09

- Expression of Claudin-3 in gastric adenocarcinoma tissue and its relation with prognosis
- Journal of Army Medical University Vol. 33, Issue 12, Pages: 1250-1252(2011)
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  CLC： R341;R730.2;R735.2
- Published：2011
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张真真,张声,余英豪,陈虹,陈余朋.Claudin-3在胃腺癌的表达及预后意义[J].陆军军医大学学报(原第三军医大学学报),2011,33(12):1250-1252.

　Zhang Zhenzhen,Zhang Sheng,Yu Yinghao,Chen Hong,Chen Yupeng.Expression of Claudin-3 in gastric adenocarcinoma tissue and its relation with prognosis[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(12):1250-1252.
张真真,张声,余英豪,陈虹,陈余朋.Claudin-3在胃腺癌的表达及预后意义[J].陆军军医大学学报(原第三军医大学学报),2011,33(12):1250-1252. DOI：

　Zhang Zhenzhen,Zhang Sheng,Yu Yinghao,Chen Hong,Chen Yupeng.Expression of Claudin-3 in gastric adenocarcinoma tissue and its relation with prognosis[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(12):1250-1252. DOI：

摘要

目的探讨Claudin-3在胃腺癌组织中的表达及其临床病理学意义以及和预后的关系。方法应用组织芯片和免疫组化S-P法检测139例胃腺癌患者正常胃黏膜腺上皮/肠化生的胃腺上皮、黏膜层、肿瘤中心、侵袭前沿区及淋巴结转移灶纵向侵袭胃癌组织Claudin-3表达的动态变化，分析Claudin-3的定位及表达水平与胃癌的临床病理学特征、侵袭转移及预后关系。结果肠化生上皮Claudin-3中-强阳性表达率为100%（36/36），高于正常胃黏膜腺上皮（17.5%，18/103，χ

=78.12，P0.05）。在胃癌组织中，Claudin-3的表达呈2种染色模式，肠型胃癌细胞Claudin-3定位于细胞膜，弥漫型胃癌细胞Claudin-3定位于细胞质，混合型胃癌细胞呈细胞膜和细胞质表达。从黏膜层、肿瘤中心、侵袭前沿及淋巴结转移灶胃癌组织，膜型染色的Claudin-3中-强阳性表达率分别为59.4%（61/88）、85.3%(75/88)、36.4%(32/88)、23.9%(21/88)，呈先升后降的抛物线趋势，肿瘤中心区表达最高，淋巴结转移灶表达最低(χ

=110.83，P0.05)，而浆型染色的Claudin-3中-强阳性表达率分别为11.8%（6/51）、33.3%(17/51)、51.0%(26/51)、15.7%(8/51)，呈逐渐升高的趋势，侵袭前沿区表达最高(χ

=31.32，P0.05)。黏膜层胃癌细胞膜型Claudin-3高表达者的术后中位生存时间高于弱表达者(χ

=9.36，P0.05)。结论胃腺癌Claudin-3的表达可能与胃癌细胞的组织学分型有关，在胃癌侵袭转移的不同部位呈异质性表达，黏膜层胃腺癌膜型Claudin-3的表达可作为胃癌患者潜在预后指标。

Abstract

Objective To study the expression of Claudin-3 in gastric adenocarcinoma tissue and its relation with the prognosis. Methods Expression of Claudin-3 was detected in normal gastric epithelium

gastric epithelium with intestinal metaplasia

mucosa layer

central area of tumor

invasive front area and lymph node metastasis of 139 patients with gastric adenocarcinoma by tissue microarray and immunohistochemistry

respectively. Relation between the location and expression of Claudin-3 in gastric adenocarcinoma

and the clini-copathological features

invasive metastasis

prognosis of gastric adenocarcinoma

were analyzed. Results The moderate-strong expression rate of Claudin-3 was significantly higher in gastric epithelium with intestinal metaplasia than in normal gastric epithelium (100.0% vs 17.5%

chi-square=78.12，P0.05）. The expression of Claudin-3 in gastric cancer tissue showed two staining patterns. Claudin-3 was located in membranes of intestinal gastric adenocarcinoma cells

in cytoplasm of diffuse gastric adenocarcinoma

and in both membranes and cytoplasm of mixed gastric adenocarcinoma. The moderate-strong expression rate of Claudin-3 with membranous staining and weak cytoplasm staining

and mixed membrane and cytoplasm staining in mucosa layer

central area of tumor

invasive front area and lymph node metastasis was 59.4%（61/88）

85.3% (75/88)，36.4% (32/88)，and 23.9% (21/88)

respectively

which increased at first and then decreased. The expression level of Claudin-3 was the highest in central area of tumor and the lowest in lymphatic metastasis (chi-square=110.83，P0.05). The moderate-strong expression rate of Claudin-3 with cytoplasm staining was 11.8%（6/51）

33.3% (17/51)，51.0% (26/51)，and 15.7% (8/51)

respectively

and was the highest in invasive front area (chi-square=31.32

P0.05). The median survival time of gastric carcinoma patients with overexpression of Claudin-3 in membrane of gastric mucosa cells was longer than those with weak expression of Claudin-3 (chi-square=9.36，P0.05). Conclusion Expression of Claudin-3 in gastric adenocarcinoma may be related with the histological typing of gastric cancer cells. Claudin-3 is heterogenetically expressed in different sites of invasive gastric metastasis. Expression of Claudin-3 in mucosa layer of gastric adenocarcinoma may be a potential prognostic marker for its prognosis.

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