Objective       To study the expression of Ezrin and intercellular adhesion molecule 1 (ICAM-1) in colon cancer and its clinical significance.      Methods        Expression of Ezrin and ICAM-1 in 32 colon cancer tissue samples and 32 its adjacent normal tissue samples was detected by immunohistochemistry S-P and Western blot

respectively. Its relation with the cliniopathological characteristics of colon cancer was analyzed.      Results       Western blot showed that Ezrin and ICAM-1 were highly expressed in colon cancer tissue samples

lowly or not expressed in normal colon tissue samples (P0.01) .The expression level of Ezrin was 2 121.0±631.5 in colon cancer tissue samples and 907.8±258.3 in its adjacent normal tissue samples

while the expression level of ICAM-1 was 2 511.5±627.2 in colon cancer tissue samples and 676.2±323.6 in its adjacent normal tissue samples (P0.01）. Immunohistochemistry demonstrated that Ezrin and ICAM-1were mainly expressed in cytomenbrane and cytoplasm. ICAM-1 was also expressed in intercellular substance. The ICAM-1 expression level was significantly higher in colon cancer tissue samples than in its adjacent normal tissue samples（P0.01）. The expression level of Ezrin and ICAM-1 was significantly higher in Dukes C+D colon cancer than in Dukes A+B colon cancer（P0.01）

and in colon cancer with lymphatic metastasis than in that without lymphatic metastasis (P0.01). The expression of Ezrin and ICAM-1 was positively related（r=0.898，P0.01）.      Conclusion        Ezrin and ICAM-1 are expressed in colon cancer tissue

and their expression levels are related with the sage and lymphatic metastasis of colon cancer.