Differential expression of zinc finger protein 266 gene in non-small cell lung carcinoma tissue with different biological behaviors and its significance

赵晓龙; 葛明建; 黎力

您当前的位置：

首页 >

文章列表页 >

Differential expression of zinc finger protein 266 gene in non-small cell lung carcinoma tissue with different biological behaviors and its significance

更新时间：2026-01-09

- Differential expression of zinc finger protein 266 gene in non-small cell lung carcinoma tissue with different biological behaviors and its significance
- Journal of Army Medical University Vol. 33, Issue 12, Pages: 1237-1239(2011)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R734.2;R394.2;R730.23
- Published：2011
- 稿件说明：
移动端阅览
赵晓龙,葛明建,黎力.不同生物学行为非小细胞肺癌组织中ZNF266基因的差异表达及意义[J].陆军军医大学学报(原第三军医大学学报),2011,33(12):1237-1239.

　Zhao Xiaolong,Ge Mingjian,Li Li.Differential expression of zinc finger protein 266 gene in non-small cell lung carcinoma tissue with different biological behaviors and its significance[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(12):1237-1239.
赵晓龙,葛明建,黎力.不同生物学行为非小细胞肺癌组织中ZNF266基因的差异表达及意义[J].陆军军医大学学报(原第三军医大学学报),2011,33(12):1237-1239. DOI：

　Zhao Xiaolong,Ge Mingjian,Li Li.Differential expression of zinc finger protein 266 gene in non-small cell lung carcinoma tissue with different biological behaviors and its significance[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(12):1237-1239. DOI：

摘要

目的观察zinc finger protein 266（ZNF266）基因在不同生物学行为非小细胞肺癌(non-small cell lung carcinoma

NSCLC)组织中的表达水平并探讨其在NSCLC发生、发展及淋巴结转移中的意义。方法选取30例不伴有淋巴结转移的NSCLC原发灶及癌旁正常组织标本和30例伴有淋巴结转移的NSCLC原发灶及淋巴结转移灶标本，采用SABC免疫组织化学三步法检测各组标本中ZNF266基因的蛋白表达水平。结果 ZNF266蛋白表达在NSCLC组织中阳性表达率显著高于癌旁正常肺组织(40% vs 7%，P0.01)；在伴有淋巴结转移的原发灶中的表达明显高于不伴有淋巴结转移的原发灶 (67% vs 40%，P0.05)；淋巴结转移灶中ZNF蛋白表达水平明显高于原发灶(93% vs 40%，P0.05)。结论 ZNF266 基因可能参与了NSCLC的发生、发展及淋巴结转移。

Abstract

Objective To study the significance of occurrence

development and lymphatic metastasis of non-small cell lung carcinoma (NSCLC) by observing the expression level of zinc finger protein 266 (ZNF266) in NSCLC tissue with differential biological behaviors. Methods Expression levels of ZNF266 in 30 samples of primary NSCLC tissue without lymphatic metastasis and its adjacent normal tissue

and in 30 samples of primary NSCLC tissue with lymphatic metastasis

were measured with the 3-step SABC immunohistochemistry method. Results The positive expression rate of ZNF266 was significantly higher in primary NSCLC tissue samples than in its adjacent normal tissue samples（40% vs 7%

P0.01)

and in primary NSCLC tissue samples with lymphatic metastasis than in those without lymphatic metastasis (67% vs 40%

P0.05).The expression level of ZNF266 was significantly higher in primary NSCLC tissue samples with lymphatic metastasis than in those without lymphatic metastasis (93% vs 67%

P0.05). Conclusion ZNF266 gene is involved in the occurrence

development and lymphatic metastasis of NSCLC.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

High expression of monocyte chemotactic protein-1 in malignant bone tumor

Expression and clinical significance of extracellular matrix protein 1 in colorectal cancer

Expression of P504s and claudin-4 in prostate cancer and prognostic value of their combined detection

Proline-rich protein 11 is highly expressed in colorectal cancer to promote cancer cell invasion and metastasis

Relationships of iduronic acid-2-sulfatase with metastasis and prognosis of colorectal cancer

Related Author

胡旭

初同伟

廖通权

余世明

刘玉刚

周跃

隆思睿

向德兵

Related Institution

No data

⁰