Electromagnetic acute irradiation leads to Th1/Th2 cytokine imbalance in mice

王源; 许商成; 张广斌; 储芳; 余争平

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Electromagnetic acute irradiation leads to Th1/Th2 cytokine imbalance in mice

更新时间：2026-01-09

- Electromagnetic acute irradiation leads to Th1/Th2 cytokine imbalance in mice
- Journal of Army Medical University Vol. 33, Issue 9, Pages: 883-886(2011)
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  CLC： R818.023;R392.11
- Published：2011
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王源,许商成,张广斌,储芳,余争平.电磁辐射急性暴露对Th1/Th2细胞因子平衡的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(09):883-886.

　Wang Yuan,Xu Shangcheng,Zhang Guangbin,Chu Fang,Yu Zhengping.Electromagnetic acute irradiation leads to Th1/Th2 cytokine imbalance in mice[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(09):883-886.
王源,许商成,张广斌,储芳,余争平.电磁辐射急性暴露对Th1/Th2细胞因子平衡的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(09):883-886. DOI：

　Wang Yuan,Xu Shangcheng,Zhang Guangbin,Chu Fang,Yu Zhengping.Electromagnetic acute irradiation leads to Th1/Th2 cytokine imbalance in mice[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(09):883-886. DOI：

摘要

目的观察电磁辐射对Th1/Th2细胞因子平衡的影响。方法以平均功率密度为90 mW/cm

的微波辐照昆明小鼠(4～6周龄，体质量20~25 g，40只，均为雌性)20 min，采用RT-PCR、ELISA检测微波辐照后不同时相点干扰素（interferon-gamma

INF-γ）、白细胞介素-4（interleukin-4

IL-4）表达量的变化，分析微波辐照对Th1/Th2平衡的偏移。 结果 90 mW/cm

的微波急性辐照会导致INF-γ表达量的增高，辐照后第5天达到峰值，增幅为135.5％（P0.01)；90 mW/cm

的微波急性辐照使IL-4的表达有降低的趋势，但与对照组相比没有显著差异（P0.05)。结论平均功率密度为90 mW/cm

的微波急性辐照会导致昆明种小鼠Th1/Th2平衡向Th1方向偏移。

Abstract

Objective To identify the effect of electromagnetic irradiation on Th1/Th2 cytokine balance. Methods A total of 40 Kunming mice were randomly divided into sham control (n=5)

and irradiation groups (1

9 and 11 d after 90 mW/cm

electromagnetic irradiation for 20 min

n=5 for each time point). The mice were sacrificed at the above correspondingly time points respectively after exposure

and their blood samples and spleen tissues were collected. The expression levels of interferon-gamma (INF-γ) and interleukin-4(IL-4) were detected with RT-PCR for spleen tissues and ELISA for blood samples. The excursion of Th1/Th2 cytokine bala

nce induced by electromagnetic irradiation was analyzed. Results INF-γ expression was obviously raised by 90 mW/cm

electromagnetic irradiation. Its serum level reached a a peak in 5 d after exposure

with an increase of 135.5% compared with sham control group (P0.01). IL-4 expression had a drawdown tendency by 90 mW/cm electromagnetic irradiation

but it had no significant difference when compared with sham control (P0.05). Conclusion Electromagnetic irradiation at 90 mW/cm

leads to the Th1/Th2 cytokine balance deflect to Th1.

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