Objective     To determine the clinical effectiveness of Heal-all oral biofilm and hydroxyapatite bioactive glass ceramic in the treatment of periodontal bone defects and periapical bone defects among 152 patients.     Methods     A total of 152 patients with periodontal and periapical bone defects were selected as subjects from our hospital from June 2006 to September 2010. After completed root canal therapy

conventional supragingival scaling，subgingival scaling and root planning

they were treated by surgical treatments including flap surgery implanting hydroxyapatite bioactive glass ceramics and oral biofilm in the bone defect area. All the patients were examined at 3 and 6 months

and 1

2

3 and 4 years by X-rays to observe the concrescence of alveolar bone and apical bone defects after treatment. Bleeding on probing (BOP)

probing depth (PD)

clinical attachment lose (CAL)

movement (M) and alveolar bone level were inspected. The therapeutic results were analyzed with SPSS15.0 soft package for Chi square test.     Results     Of the 152 cases

138 were cured during the follow-up period of 1 to 4 years

with the cure rate of 90.8%

and 14 cases failed to the treatment with the failure rate of 9.2%. The value of PD was changed from the baseline of (5.80±0.86) mm to (3.33±0.64) mm in 6 months after the treatment (P0.05). The value of CAL was obviously changed from the baseline of (6.10±0.83) mm to (3.52±0.32) mm in 6 months after the treatment (P0.05).     Conclusion     As materials of bone tissue bracket

Heal-all oral biofilm and hydroxyapatite (HAP) can be wildly used in the areas of bone restoration and bone substitute. It is effective in the clinical treatment and will be widely used in the bone engineering.