Objective    To explore the influence of specific Dermatophagoides pteronyssinus allergen preparation on pulmonary function

airway responsiveness

serum Dermatophagoides pteronyssinus-specific IgG

4

and serum Dermatophagoides pteronyssinus-specific IgE of children suffering from allergic asthma.     Methods     Thirty-one children with mil

d-to-moderate dermatophagoides pteronyssinus allergic asthma were treated with specific immunotherapy using Dermatophagoides pteronyssinus allergen preparation for 25 weeks. The pulmonary function indexes

including percentages of FEV1 and PEF to their forecast values and PC20

as well as serum Dermatophagoides pteronyssinus-specific IgG

4

level and serum Dermatophagoides pteronyssinus-specific IgE level were determined before and after the specific immunotherapy.      Results     After the specific immunotherapy

the percentages of FEV1 and PEF compared with their forecast values increased from (97.87±23.44)% and (99.95±29.52)% to (114.81±17.65)% and (116.51±19.52)%

respectively (P0.01). PC20 increased from 1.49±2.75 mg/ml to 7.31±7.02 mg/ml (P0.01). Serum Dermatophagoides pteronyssinus-specific IgG

4

level and serum Dermatophagoides pteronyssinus-specific IgE level changed from 271.4 AU/ml (436.6 AU/ml) and 87.14 AU/ml (70.26 AU/ml) to 2 450.5 AU/ml (2 771.95 AU/ml) and 100.00 AU/ml (59.25 AU/ml)

respectively

indicating insignificant difference of specific IgE level (P0.05) but significant increase of specific IgG

4

level (P0.01).     Conclusion     Specific immunotherapy can significantly improve the pulmonary function of children suffering from allergic asthma. The increase of serum Dermatophagoides pteronyssinus-specific IgG

4

plays an important role in immunotherapy of asthma.