Effects of cinepazide maleate on IL-1β and IL-6 expression and neural function in rats after focal cerebral ischemia/reperfusion

黄艳玲; 秦新月; 王恬竹; 吴小慧

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Effects of cinepazide maleate on IL-1β and IL-6 expression and neural function in rats after focal cerebral ischemia/reperfusion

更新时间：2026-01-09

- Effects of cinepazide maleate on IL-1β and IL-6 expression and neural function in rats after focal cerebral ischemia/reperfusion
- Journal of Army Medical University Vol. 33, Issue 6, Pages: 596-599(2011)
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  CLC： R743.31;R392.11;R972
- Published：2011
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黄艳玲,秦新月,王恬竹,吴小慧.马来酸桂哌齐特对大鼠局灶性脑缺血再灌注后白介素-1β、白介素-6的表达及神经功能的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(06):596-599.

　Huang Yanling,Qin Xinyue,Wang Tianzhu,Wu Xiaohui.Effects of cinepazide maleate on IL-1β and IL-6 expression and neural function in rats after focal cerebral ischemia/reperfusion[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(06):596-599.
黄艳玲,秦新月,王恬竹,吴小慧.马来酸桂哌齐特对大鼠局灶性脑缺血再灌注后白介素-1β、白介素-6的表达及神经功能的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(06):596-599. DOI：

　Huang Yanling,Qin Xinyue,Wang Tianzhu,Wu Xiaohui.Effects of cinepazide maleate on IL-1β and IL-6 expression and neural function in rats after focal cerebral ischemia/reperfusion[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(06):596-599. DOI：

摘要

目的研究马来酸桂哌齐特(cinepazide maleate

CM)对大鼠急性脑缺血后IL-1β、IL-6的表达及神经功能的影响。方法成年雄性SD大鼠48只，采用随机数字表法分为正常组、假手术组、缺血再灌注组及CM治疗组，在缺血再灌注后第2、7 天对脑组织进行HE染色、测定脑组织含水量及采用免疫组化法测定皮质IL-1β、IL-6的表达，并对动物进行神经功能评分。结果脑缺血再灌注后第2天，CM治疗组与缺血再灌注组比较，脑内有较多的神经细胞存活，IL-1β、IL-6的表达被明显抑制(P0.01)，但是CM治疗组脑组织含水量及神经功能评分与缺血再灌注组比较无明显改善(P0.05)。至缺血再灌注后第7天，缺血再灌注组IL-1β、IL-6的表达较早期有所降低(P0.01)，同时伴随神经功能的改善(P0.05)，CM治疗组的改善更为明显(P0.01)。结论 CM对大鼠局灶性脑缺血再灌注损伤有一定的脑保护作用，其作用机制可能与CM降低脑内IL-1β、IL-6的表达有关。

Abstract

Objective To study the effects of cinepazide maleate (CM) on the expression of IL-1β and IL-6 and neural function in rats after acute cerebral ischemia. Methods Forty-eight adult male SD rats were randomly divided into a control group

a sham operation group

an ischemia/reperfusion group

and a CM treatment group. On the 2nd and 7th days after ischemia/reperfusion

HE staining and immunohistochemical assay were employed to observe pathological changes of brain tissue and detect IL-1β and IL-6 expression in the cerebral cortex. Additionally

the water content of brain tissue and the neurological function scores of experimental animals were determined. Results On the 2nd day after acute cerebral ischemia

the CM treatment group exhibited more survived nerve cells

significantly inhibited expression of IL-1β and IL-6 (P0.01) and no obvious improvement about the brain water content and neurological function score (P0.05) in comparison with the ischemia/reperfusion group. On the 7th day after acute cerebral ischemia

the expression of IL-1β and IL-6 in the ischemia/reperfusion group decreased as compared with a previous level (P0.01)

accompanied by improvement in neurological function (P0.05). Such changes in the CM treatment group were more significant (P0.01). Conclusion CM has certain cerebroprotective effects against cerebral ischemia/reperfusion injury in rats

the underlying mechanism of which may be associated with CM inhibiting IL-1β and IL-6 expression in brain tissue.

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