Objective   To evaluate the efficacy and toxicity of induction chemotherapy involving nedaplatin (NDP) and tegafur (FT-207) in treatment of locally advanced nasopharyngeal carcinoma(NPC).   Methods   Sixty patients

who were newly diagnosed and pathologically proven as NPC at III and IVa stages and admitted in our department from May 2003 to July 2010

were

assigned to 2 groups (n=30). All patient characteristics of the 2 groups were well balanced. They underwent an induction chemotherapy with NDP combined with FT-207 (NDP 30 mg/m

2

d1-3；FT-207 600 mg/m

2

d1-5; CF 0.2 g，d1-5) or DDP combined with 5-FU（DDP 30 mg/m

2

，d1-3；5-FU 500 mg/m

2

，d1-5；CF 0.2 g，d1-5） for 21 d as one cycle respectively for 2 cycles. The clinical efficacy and toxicity were evaluated after the induction chemotherapy and radiotherapy. Meanwhile the comparative study was made between the 2 groups.   Results   All of cases were eligible for clinical response evaluation. Similar clinical complete response rate and partial response rate  were observed between the 2 groups (83.3% vs 70.0%

and 13.3% vs 30.0% respectively

P＞0.05). There was no significant difference in incidence of grade III and IV toxicity including granulocytopenia in the observer group and the control group (6.6% vs 3.3%

P＞0.05). However significant difference was found in incidence of vomiting  between the 2 groups(6.7% vs 26.7%

P0.05).   Conclusion   Our study indicates that induction chemotherapy with nedaplatin and tegafur is a safe and effective regimen for patients with locally advanced nasopharyngeal carcinoma.