Effect of Matrine injection on liver function of patients with primary liver cancer due to HB virus infection after transarterial chemoembolization

张志红; 倪秉强; 陈日新

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Effect of Matrine injection on liver function of patients with primary liver cancer due to HB virus infection after transarterial chemoembolization

更新时间：2026-01-09

- Effect of Matrine injection on liver function of patients with primary liver cancer due to HB virus infection after transarterial chemoembolization
- Journal of Army Medical University Vol. 32, Issue 23, Pages: 2552-2555(2010)
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  CLC： R282.71;R333.4;R735.7
- Published：2010
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张志红,倪秉强,陈日新.苦参素注射液对感染乙肝病毒的原发性肝癌患者TACE术后肝功能的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(23):2552-2555.

　Zhang Zhihong,Ni Bingqiang,Chen Rixin.Effect of Matrine injection on liver function of patients with primary liver cancer due to HB virus infection after transarterial chemoembolization[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(23):2552-2555.
张志红,倪秉强,陈日新.苦参素注射液对感染乙肝病毒的原发性肝癌患者TACE术后肝功能的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(23):2552-2555. DOI：

　Zhang Zhihong,Ni Bingqiang,Chen Rixin.Effect of Matrine injection on liver function of patients with primary liver cancer due to HB virus infection after transarterial chemoembolization[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(23):2552-2555. DOI：

摘要

目的观察原发性肝癌经导管肝动脉栓塞术及栓塞化疗术（transartrirl chemotheryemblization，TACE）术后乙肝活动状态及苦参素注射液对术后肝功能的影响。方法 2007年8月至2009年12月我院收治76例感染乙肝病毒的原发性肝癌患者，采用区组化随机分为治疗组（TACE术+苦参素注射液，38例）和对照组（TACE术＋还原型谷胱甘肽，38例），TACE术前及术后第3天、第4周末、第12周末检测肝功能，术前及术后第4周末、第12周末检测HBV-DNA载量。结果治疗后2组血清HBV-DNA载量均增高（P0.05）。在治疗第12周末，治疗组、对照组血清HBV-DNA载量分别为（5.82±1.25、7.29±1.53

P0.05）。在治疗第3天、第4周末、第12周末，对照组和治疗组ALT/AST同期比较差异有统计学意义（P0.05）。2组肝炎活动发生率比较差异有统计学意义（P0.05）。结论原发性肝癌TACE术后可引起乙肝病毒再激活，并导致肝炎活动，苦参素注射液能改善肝功能，对肝病毒再激活引起的肝损害有保护作用和一定的抗病毒作用。

Abstract

Objective To study the effect of Matrine injection on liver function of patients with primary liver cancer due to HB virus infection after transarterial chemoembolization (TACE). Methods Seventy-six patients with primary liver cancer due to HB virus infection admitted to our hospital from August 2007 to December 2009 were randomly divided into treatment group (TACE+Matrine injection

n=38) and control group (TACE+glutathione

n=38). Liver function was detected on day 3

and weeks 4 and 12 after TACE. HBV-DNA load was assayed in 4 and 12 weeks before TACE

respectively. Results The HBV-DNA load was 5.82±1.25 in treatment group and 7.29±1.53 in control group 12 weeks after TACE（P0.05）. The ALT/AST was significantly different between the control group and treatment group on day 3

and weeks 4 and 12 after TACE (P0.05). The incidence of hepatitis was significantly different between the two groups (P0.05). Conclusion Primary liver cancer after TACE can reactivate hepatitis B virus. Matrine injection can improve liver function

protect liver against damage induced by reactivation of hepatitis B virus and has a certain antiviral effect.

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