Expression of mammalian target of rapamycin and eIF4E signal pathway in cerebral glioma and its clinical significance

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Expression of mammalian target of rapamycin and eIF4E signal pathway in cerebral glioma and its clinical significance

更新时间：2026-01-09

- Expression of mammalian target of rapamycin and eIF4E signal pathway in cerebral glioma and its clinical significance
- Journal of Army Medical University Vol. 32, Issue 23, Pages: 2549-2551(2010)
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  CLC： R394.2;R730.23;R739.41
- Published：2010
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李进军,刘献志,万学峰,徐斌.mTOR/eIF4E信号通路在不同级别人脑胶质瘤组织中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2010,32(23):2549-2551.

　Li Jinjun,Liu Xianzhi,Wan Xuefeng,Xu Bin.Expression of mammalian target of rapamycin and eIF4E signal pathway in cerebral glioma and its clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(23):2549-2551.
李进军,刘献志,万学峰,徐斌.mTOR/eIF4E信号通路在不同级别人脑胶质瘤组织中的表达及临床意义[J].陆军军医大学学报(原第三军医大学学报),2010,32(23):2549-2551. DOI：

　Li Jinjun,Liu Xianzhi,Wan Xuefeng,Xu Bin.Expression of mammalian target of rapamycin and eIF4E signal pathway in cerebral glioma and its clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(23):2549-2551. DOI：

摘要

目的研究mTOR/eIF4E信号通路在不同级别人脑胶质瘤组织中的表达情况及临床意义。方法采用免疫组化S-P法分别检测在31例低级别胶质瘤（Ⅰ、Ⅱ级）和33例高级别胶质瘤(Ⅲ、Ⅳ级)以及10例正常脑组织中mTOR和eIF4E蛋白的表达情况，并分析mTOR和eIF4E蛋白表达与相关临床参数的关系。结果与正常脑组织相比，mTOR和eIF4E在人脑胶质瘤中的表达均显著增加；在高级别胶质瘤中，两者的阳性表达率(78.79%、78.79%)显著高于低级别组（35.48%、45.16%，P0.05），且mTOR和eIF4E蛋白表达具有显著正相关性(r=0.449，P0.01)。结论 mTOR和eIF4E在脑胶质瘤中的表达明显增加，mTOR/eIF4E信号通路可能在脑胶质瘤的发生、发展中起一定作用。

Abstract

Objective To study the expression of mammalian target of rapamycin (mTOR) and eIF4E signal pathway in human cerebral glioma and its clinical significance. Methods Expression of mTOR and eIF4E was detected in 31 glioma tissue samples

33 advanced glioma tissue samples

and 10 normal brain tissue samples by S-P immunohistochemistry. Correlation between mTOR and eIF4E expressions and related clinical data was analyzed. Results The expression level of mTOR and eIF4E was significantly higher in human cerebral glioma tissue samples than in normal cerebral tissue samples. The expression rate of mTOR and eIF4E was significantly higher in advanced glioma tissue samples in mild and moderate glioma tissue samples (78.79% and 78.79% vs 35.48% and 45.16%

P0.05). There was a positive correlation between mTOR gene and eIF4E expressions in human glioma (r=0.449

P0.01). Conclusion Expression of mTOR and eIF4E in human cerebral glioma is significantly increased. mTOR/eIF4E signal pathway may play a certain role in the occurrence and development of cerebral glioma.

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