Influence of different administration ways on pharmacokinetics of levofloxacin in prostate of bacterial prostatitis rats

曾洋; 肖明朝; 周远大

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Influence of different administration ways on pharmacokinetics of levofloxacin in prostate of bacterial prostatitis rats

更新时间：2026-01-09

- Influence of different administration ways on pharmacokinetics of levofloxacin in prostate of bacterial prostatitis rats
- Journal of Army Medical University Vol. 33, Issue 4, Pages: 385-388(2011)
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  CLC： R697.3;R969.1;R978.69
- Published：2011
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曾洋,肖明朝,周远大.给药途径对左氧氟沙星在模型大鼠前列腺组织中药动学的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(04):385-388.

　Zeng Yang,Xiao Mingchao,Zhou Yuanda.Influence of different administration ways on pharmacokinetics of levofloxacin in prostate of bacterial prostatitis rats[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(04):385-388.
曾洋,肖明朝,周远大.给药途径对左氧氟沙星在模型大鼠前列腺组织中药动学的影响[J].陆军军医大学学报(原第三军医大学学报),2011,33(04):385-388. DOI：

　Zeng Yang,Xiao Mingchao,Zhou Yuanda.Influence of different administration ways on pharmacokinetics of levofloxacin in prostate of bacterial prostatitis rats[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(04):385-388. DOI：

摘要

目的结合前期口服给药的实验结果，分析在静脉、口服两种不同给药途径中，左氧氟沙星在模型大鼠前列腺组织中药动学的差异。方法将60只细菌性前列腺炎模型大鼠静脉注射左氧氟沙星注射液（44 mg/kg），分别于给药后1、3、7.5、15、30、60、120、240、480、720 min采集动物前列腺标本并制作成组织匀浆。HPLC法测定各组织中左氧氟沙星浓度，3p97软件计算药动学参数。其结果与前期口服给药结果进行对比分析。结果静脉给药的药时曲线符合二室模型，主要动力学参数如下：t

1/2β

（2.1±0.7）h、t

max

（0.6±0.2）h、C

max

（72.3±23.3）μg/g及AUC

0-12

（253.7±91.7）μg/（h·g）。与前期口服给药相比，t

1/2β

、t

max

、C

max

及AUC

0-12

在两种不同给药途径下有显著性差异（P0.01）。结论静脉给药能够明显提高左氧氟沙星在前列腺炎组织中的药物分布浓度，而口服给药能够显著延长其在前列腺炎组织中的半衰期。

Abstract

Objective To explore the pharmacokinetic differences of levofloxacin by intravenous injection and oral administration in the prostate of rat model of prostatitis. Methods A total of 60 rats were inflicted with 0.1 ml 1.8×10

cfu/ml E. coli injection in their prostates to establish prostatitis model. On the basis of previous oral administration experiment

these 60 rats with bacterial prostatitis were injected levofloxacin (44 mg/kg)

then the tissue of prostate was collected in 1

7.5

120

240

480 and 720 min after administration and made into homogenate. The concentration of levofloxacin was detected by HPLC

and pharmacokinetic parameters were calculated with 3p97 software program. The results were compared with data from previous oral administration. Results The concentration curves based on drug-time of intravenous injection was presented by two-compartments model. The main pharmacokinetic parameters were: t

1/2β

2.1±0.7 h

max

0.6±0.2 h

max

72.3±23.3 μg/g and AUC

0-12

253.7±91.7 μg/（h·g）. Compared with data from previous oral administration

1/2β

max

and AUC

0-12

had significant differences among the 2 different ways of administration (P0.01). Conclusion Intravenous injection can significantly increase the concentration of levofloxacin in the tissue of prostatitis

while oral administration can significantly prolong its half life in the tissue of prostatitis.

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