Expressions of CEACAM6 and MMP-9 in gastric carcinoma and their relationship with clinicopathological features: report of 54 cases

潘海邦; 王波; 杨爱军; 关泉林

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Expressions of CEACAM6 and MMP-9 in gastric carcinoma and their relationship with clinicopathological features: report of 54 cases

更新时间：2026-01-09

- Expressions of CEACAM6 and MMP-9 in gastric carcinoma and their relationship with clinicopathological features: report of 54 cases
- Journal of Army Medical University Vol. 32, Issue 24, Pages: 2632-2635(2010)
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  CLC： R730.23;R730.43;R735.2
- Published：2010
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潘海邦,王波,杨爱军,关泉林.胃癌组织中CEACAM6、MMP-9的表达及其与临床病理的关系[J].陆军军医大学学报(原第三军医大学学报),2010,32(24):2632-2635.

　Pan Haibang,Wang Bo,Yang Aijun,Guan Quanlin.Expressions of CEACAM6 and MMP-9 in gastric carcinoma and their relationship with clinicopathological features: report of 54 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(24):2632-2635.
潘海邦,王波,杨爱军,关泉林.胃癌组织中CEACAM6、MMP-9的表达及其与临床病理的关系[J].陆军军医大学学报(原第三军医大学学报),2010,32(24):2632-2635. DOI：

　Pan Haibang,Wang Bo,Yang Aijun,Guan Quanlin.Expressions of CEACAM6 and MMP-9 in gastric carcinoma and their relationship with clinicopathological features: report of 54 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(24):2632-2635. DOI：

摘要

目的探讨CEACAM6、MMP-9在胃癌组织中的表达及其与微血管生成之间的关系。方法免疫组化法分别检测CEACAM6、MMP-9在54例胃癌组织及10例胃正常组织中的表达情况及与微血管密度（microvessel density，MVD）表达的相关性。结果 CEACAM6、MMP-9在胃癌组织中表达率分别为85.19%（46/54）、74.7％（40/54），明显高于胃正常组织中表达率30%（3/10）、20％（2/10），胃癌组织中MVD值（32.17±8.97）明显高于胃正常组织[（18.62±5.07)，P0.05）]。胃癌组织中CEACAM6与性别、年龄、分化程度和淋巴结转移无关（P0.05）；而与浸润深度、临床分期有关（P0.05）。MMP-9和MVD与性别、年龄无关（P0.05）；而与浸润深度、临床分期、分化程度及淋巴结转移有关（P0.05）；CEACAM6与MMP-9在胃癌组织中的表达呈正相关（r=0.593，P=0.000）；CEACAM6、MMP-9阳性表达的MVD明显高于相应阴性表达（P0.05）。结论 CEACAM6、MMP-9在胃癌组织中高表达，可能参与了胃癌的发生、发展，与胃癌微血管生成和浸润、转移有关。

Abstract

Objective To investigate the expressions of CEACAM6 (CD66c) and MMP-9 in gastric cancer tissue and their relationship with tumor micro-angiogenesis. Methods Immunohistochemistry was used to detect the expressions of CEACAM6 and MMP-9

and microvessel density (MVD) in 54 samples of gastric cancer and 10 normal gastric tissue. The clinical data were retrospectively analyzed. Results The positive rates of CEACAM6 and MMP-9 in gastric carcinoma tissue were 85.19% (46/54) and 74.7% (40/54)

respectively

which were significantly higher than those in normal gastric tissue [30.00% (3/10)

20.00% (2/10)

respectively

P0.05]. The value of MVD in gastric cancer tissue was 32.17±8.97

which was significantly higher than that in normal gastric tissue (18.62±5.07

P0.05). The expression of CEACAM6 was associated significantly with depth of invasion and clinical stage of gastric cancer (P0.05)

but was not associated with gender

age

differentiation and lymph node metastasis (P0.05). The expression of MMP-9 and the value of MVD were associated significantly with depth of invasion

clinical stage

differentiation and lymph node metastasis of gastric cancer (P0.05)

but they had no relation with gender and age (P0.05). There was a significantly positive correlation between CEACAM6 expression and MMP-9 expression in gastric cancer tissue (r=0.593

P=0.000). The value of MVD in the individuals with positive expression of CEACAM6 or MMP-9 was significantly higher than that in the patients negative to CEACAM6 or MMP-9 (P0.05). Conclusion Moderate and strong expressions of MMP-9 and CEACAM6 in gastric cancer tissue are associated with tumor micro-angiogenesis

invasion and metastasis

which may contribute to the occurrence and development of gastric cancer.

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