Relationship of serum MIF level and -173G/C polymorphism with tuberculosis: a retrospective study on 68 cases

邓少丽; 李艳林; 陈鸣; 陈伟; 黄恒柳; 夏季; 张海峰

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Relationship of serum MIF level and -173G/C polymorphism with tuberculosis: a retrospective study on 68 cases

更新时间：2026-01-09

- Relationship of serum MIF level and -173G/C polymorphism with tuberculosis: a retrospective study on 68 cases
- Journal of Army Medical University Vol. 32, Issue 24, Pages: 2616-2618(2010)
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  CLC： R394.3;R446.139;R520.2
- Published：2010
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邓少丽,李艳林,陈鸣,陈伟,黄恒柳,夏季,张海峰.MIF水平及MIF-173 G/C多态性与结核病关系研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(24):2616-2618.

　Deng Shaoli,Li Yanlin,Chen Ming,Chen Wei,Huang Hengliu,Xia Ji,Zhang Haifeng.Relationship of serum MIF level and -173G/C polymorphism with tuberculosis: a retrospective study on 68 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(24):2616-2618.
邓少丽,李艳林,陈鸣,陈伟,黄恒柳,夏季,张海峰.MIF水平及MIF-173 G/C多态性与结核病关系研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(24):2616-2618. DOI：

　Deng Shaoli,Li Yanlin,Chen Ming,Chen Wei,Huang Hengliu,Xia Ji,Zhang Haifeng.Relationship of serum MIF level and -173G/C polymorphism with tuberculosis: a retrospective study on 68 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(24):2616-2618. DOI：

摘要

目的研究结核病患者巨噬细胞移动抑制因子（migration inhibitory factor，MIF）表达水平，分析MIF-173G/C多态性与结核杆菌易感性关系。方法选取第三军医大学大坪医院野战外科研究所呼吸科2009年9月至2010年9月结核病患者68例及70例健康体检者，采用RFLP-PCR的方法分析2组MIF-173基因型，ELISA法检测血清中MIF水平。结果结核病组中MIF-173 CC纯合基因型及MIF-173*C等位基因频率较正常对照组明显升高（OR值分别为3.99和1.58，P=0.003和0.02），结核组MIF水平明显高于对照组[（705.21±67.98 ）pg/ml vs （355.31±57.29）pg/ml，P0.01]，表达水平平均升高1倍左右。结论 MIF-173*C基因型与结核杆菌易感有关，在结核病发病中可能发挥重要作用。

Abstract

Objective To analyze the serum level of macrophage migration inhibitory factor (MIF)in tuberculosis patients and evaluate the potential relationship of its level and -173G/C polymorphism with tuberculosis. Methods A total of 68 tuberculosis patients who admitted in our hospital from September 2009 to September 2010 and a matched control group of 70 healthy volunteers in the same period were included in this study. Their blood samples were collected. MIF-173 G/C was genotyped by using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Serum MIF level was detected by ELISA. Results The numbers of patients who carrying with MIF-173 C/C and MIF-173 *C were much larger than those of healthy control (OR=3.99

1.58). The serum MIF level in tuberculosis patients was also higher than control (705.21±67.98 vs 355.31±57.29 pg/ml，P0.01). Conclusion The C genotype of MIF-173 locus may be associated with the risk of tuberculosis and play a certain role in the incidence.

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