Objective To study the correlation of recurrent miscarriage with semen parameters

teratozoo - spermia and DNA integrity. Methods Based on the inclusion criteria

sperm specimens collected in our hospital from April 2007 to April 2009 were divided into 3 groups: the recurrent miscarriage group (

n

=49)

the pregestational group (

n

=60) and the nor

mal fertility group (

n

=39). The semen morphology was observed by papanicolaou ’ s staining using Kruger ’ s strict criteria

in the meanwhile

semen was also studied using CASA technology. Some specimens of the recurrent miscarriage group and the normal fertility group were optimized through the swim - up method

and sperm chromatin structure assay was used to measure the levels of the sperm DNA integrity of the specimens before and after the optimization. Results There was a very significant difference in the total malformation rate

and head malformation rate between the pregestational group and the normal fertility group (

P

0 . 01)

a significant difference in the concentration and mobility and forward mobility of sperm between the recurrent miscarriage group and the pregestational group (

P

0 . 05)

and a very significant difference in these between the recurrent miscarriage group and the normal fertility group (

P

0 . 01). A significant difference was found in the concentration

the head and total malformation rate between the pregestational group the normal fertility group (

P

0 . 05)

and no significant difference in the mobility and forward mobility of sperm between the 2 groups (

P

0 . 05). The sperm DNA damage index COMP in the recurrent miscarriage group [(16.57 ± 6.32)%

]

before optimization with swim - up method showed a significant difference with that in the normal fertility group [(12.56 ± 5.00)%

]

(

P

0 . 05)

and no significant difference was found between recurrent miscarriage group [(13.46 ± 3.51)%

]

after optimization and normal fertility group (

P

0 . 05). There was a moderate correlation between COMP and concentration

mobility

forward mobility of sperm

the rate of A grade sperm (A%)

the rate of B grade sperm (B%)

the rate of C grade sperm (C%)

total malformation rate

and head malformation rate (

r

=-0.421

-0.652

-0.569

-0.457

-0 . 511

-0.453

0.474

0.513

respectively

P

0 . 01). Conclusion There is a correlation

between the recurrent miscarriage and the sperm quality of the husband

but the related mechanism between the two needs further study.