Correlation between vitamin A and erythropoietin levels in preschool children of Banan district of Chongqing

刘永芳; 龚敏; 陈立; 江伟; 刘友学; 陈洁; 瞿平; 李廷玉

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Correlation between vitamin A and erythropoietin levels in preschool children of Banan district of Chongqing

更新时间：2026-01-09

- Correlation between vitamin A and erythropoietin levels in preschool children of Banan district of Chongqing
- Journal of Army Medical University Vol. 32, Issue 13, Pages: 1456-1458(2010)
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  CLC： R153.2;R195;R556
- Published：2010
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刘永芳,龚敏,陈立,江伟,刘友学,陈洁,瞿平,李廷玉.重庆市巴南地区学龄前儿童维生素A营养状况与红细胞生成素水平的关系[J].陆军军医大学学报(原第三军医大学学报),2010,32(13):1456-1458.

　Liu Yongfang,Gong Min,Chen Li,Jiang Wei,Liu Youxue,Chen Jie,Qu Ping,Li Tingyu.Correlation between vitamin A and erythropoietin levels in preschool children of Banan district of Chongqing[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(13):1456-1458.
刘永芳,龚敏,陈立,江伟,刘友学,陈洁,瞿平,李廷玉.重庆市巴南地区学龄前儿童维生素A营养状况与红细胞生成素水平的关系[J].陆军军医大学学报(原第三军医大学学报),2010,32(13):1456-1458. DOI：

　Liu Yongfang,Gong Min,Chen Li,Jiang Wei,Liu Youxue,Chen Jie,Qu Ping,Li Tingyu.Correlation between vitamin A and erythropoietin levels in preschool children of Banan district of Chongqing[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(13):1456-1458. DOI：

摘要

目的了解重庆市巴南地区学龄前儿童的维生素A（vitamin A

VA）营养状况，全血中血红蛋白（hemoglobin

Hb）及红细胞生成素（erythropoietin

EPO）的水平，进一步探讨VA缺乏与贫血的相关机制。方法采用分层与整群抽样相结合的方法，在重庆市巴南区鱼洞镇7所规模200名的幼儿园中随机选取3所中的所有3~6岁符合纳入标准的349名学龄前儿童。采用反相高效液相色谱法（high-performance liquid chromatography， HPLC）测静脉血中血清VA浓度，化学发光免疫测定法测定EPO浓度，氰化高铁法测量Hb浓度，并分析相关性。结果该地区学龄前儿童VA缺乏、边缘型VA缺乏及贫血发生率分别为1.72%、22.64%和22.64%；VA缺乏较VA正常儿童贫血的发生率有显著性差异（P0.05），VA缺乏儿童的贫血发生率是VA正常儿童的2.32倍。Hb水平与EPO浓度呈显著性负相关（P0.01）。贫血儿童较正常Hb水平儿童，EPO有显著差异（P0.05）。在贫血儿童中，低VA水平（vitamin A1.05 μmol/L）儿童Hb浓度与EPO水平呈较强负相关（r=－0.46

P0.05）；在总体学龄前儿童中，低VA水平较VA正常儿童Hb浓度与EPO水平有较强的负相关性（r=－0.23，r=－0.16，P0.05），Lg(EPO)与Hb回归方程斜率低VA较VA正常儿童增加0.000 2。结论机体VA的营养水平影响Hb浓度对EPO的反馈性调节作用。

Abstract

Objective To study the correlation of vitamin A (VA) with hemoglobin (Hb) and erythropoietin (EPO) levels in preschool children of Banan district of Chongqing

and the mechanism underlying the correlation between VA deficiency and anemia. Methods A total of 349 preschool children meeting the inclusion criteria were randomly recruited from 3 kindergartens in Banan district of

Chongqing. Serum VA

EPO

and Hb levels were measured by highperformance liquid chromatography (HPLC)

chemiluminescent immunoassay

and cyanmethemoglobin determination method

respectively

and their correlation was analyzed. Results The rate of VA deficiency

suspicious sub-clinical VA deficiency and anemia was 1.72%

22.64%

and 22.64%

respectively

in preschool children of Banan district of Chongqing (P0.05). The incidence of anemia was 2.32-fold higher in children with a lower VA level than in those with a normal VA level. The EPO level was significantly higher in children with anemia than in those without anemia (P0.05). The Hb level was negatively correlated with the EPO level in children with anemia (r=-0.46

P0.05). Log

regression equation showed that the slope of VA increased by 0.000 2 compared with normal VA. Conclusion VA level can influence the feedback regulatory effect of Hb on EPO level.

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