Effect of letrozole on ovulation in patients with polycystic ovary syndrome

胡敏; 丘彦

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Effect of letrozole on ovulation in patients with polycystic ovary syndrome

更新时间：2026-01-09

- Effect of letrozole on ovulation in patients with polycystic ovary syndrome
- Journal of Army Medical University Vol. 32, Issue 13, Pages: 1449-1451(2010)
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  CLC： R711.605;R711.75;R979.23
- Published：2010
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胡敏,丘彦.来曲唑对多囊卵巢综合征患者促排卵作用的研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(13):1449-1451.

　Hu Min,Qiu Yan.Effect of letrozole on ovulation in patients with polycystic ovary syndrome[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(13):1449-1451.
胡敏,丘彦.来曲唑对多囊卵巢综合征患者促排卵作用的研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(13):1449-1451. DOI：

　Hu Min,Qiu Yan.Effect of letrozole on ovulation in patients with polycystic ovary syndrome[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(13):1449-1451. DOI：

摘要

目的探讨来曲唑(letrozole，LE)用于多囊卵巢综合征(polycystic ovary syndrome

PCOS)患者的促排卵疗效。方法筛选我科2008年3月至2009年3月间门诊164例(共367个月经周期）PCOS患者分别用LE(68例，LE组)及枸橼酸克罗米芬（chloramiphene

CC） (96例，CC组)促排卵治疗。监测、评价两组治疗前后卵泡生长率、血清激素，子宫内膜生长、宫颈黏液性状变化情况。结果卵泡生长速率LE组与CC组分别为1.67 mm/d、1.78 mm/d(P=0.14)。睾酮（testosterone

T）水平黄体生成激素（luteinizing hormane

LH）峰日LE组与CC组分别为（2.1±1.9）ng/dl，（2.0±1.7）ng/dl (P=0.93)，LE组T水平LH峰日与月经第3天分别为（2.1±1.9）ng/dl，（1.4±1.5）ng/dl (P=0.09)。雌二醇（estradiol

）水平LH峰日LE组与CC组分别为（89.0±59.5）pg/ml

（108.1±46.0）pg/ml (P=0.13)。子宫内膜厚度LH峰日LE组与CC组分别为（11.3±1.6） mm

（9.7±1.4）mm (P=0.07)，宫颈黏液评分LE组与CC组分别为（11.0±1.1）分，（8.3±3.1）分 (P=0.003)。结论 LE用于多囊卵巢综合征不孕患者诱导排卵有效，治疗未加重雄激素水平异常。

Abstract

Objective To study the effect of letrozole (LE) on ovulation in patients with polycystic ovary syndrome (PCOS). Methods One hundred and sixtyfour patients with PCOS were divided into LE treatment group (n=68) and chloramiphene (CC) treatment group (n=96). Growth rate of follicles

serum hormone level

endometrial thickness

and cervix mucus were observed before and after treatment. Results The growth ra

te of follicles was 1.67 and 1.78 mm/d

respectively

in LE and CC treatment groups (P=0.14). The serum T level on the day of LH peak was 2.1±1.9 and 2.0±1.7ng/dL

respectively

in LE and CC treatment groups (P=0.93). The serum testosterone (T) level on day of LH peak and on day 3 of menses was 2.1±1.9 and 1.4±1.5 ng/d

respectively

in LE and CC treatment groups (P=0.09). The serum E

level on day of LH peak was 89.0±59.5 and 108.1±46.0 pg/ml

respectively

in LE and CC treatment groups (P=0.13). The endometrial thickness was 11.3±1.6 and 9.7±1.4 mm

respectively

in LE and CC treatment groups (P=0.07) .The score of cervix mucus was 11.0±1.1 and 8.3±3.1

respectively

in LE and CC treatment groups (P=0.003). Conclusion Letrozole can effectively induce ovulation in patients with polycystic ovary syndrome

and does not increase serum T level.

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