Relation between platelet-derived growth factor, foxp3, MMP-9 and airway remodeling due to asthma

杜建新; 蒋悍东; 杜春华; 成炜; 王丽娜; 郭成浩

您当前的位置：

首页 >

文章列表页 >

Relation between platelet-derived growth factor, foxp3, MMP-9 and airway remodeling due to asthma

更新时间：2026-01-09

- Relation between platelet-derived growth factor, foxp3, MMP-9 and airway remodeling due to asthma
- Journal of Army Medical University Vol. 32, Issue 21, Pages: 2329-2332(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R322.33;R392.3;R562.25
- Published：2010
- 稿件说明：
移动端阅览
杜建新,蒋悍东,杜春华,成炜,王丽娜,郭成浩.PDGF、foxp3和MMP-9与哮喘气道重塑的关系研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(21):2329-2332.

　Du Jianxin,Jiang Handong,Du Chunhua,Cheng Wei,Wang Lina,Guo Chenghao.Relation between platelet-derived growth factor, foxp3, MMP-9 and airway remodeling due to asthma[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(21):2329-2332.
杜建新,蒋悍东,杜春华,成炜,王丽娜,郭成浩.PDGF、foxp3和MMP-9与哮喘气道重塑的关系研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(21):2329-2332. DOI：

　Du Jianxin,Jiang Handong,Du Chunhua,Cheng Wei,Wang Lina,Guo Chenghao.Relation between platelet-derived growth factor, foxp3, MMP-9 and airway remodeling due to asthma[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(21):2329-2332. DOI：

摘要

目的探讨PDGF、foxp3和MMP-9与哮喘气道重塑的关系。方法采用双抗体夹心ELISA法检测40例哮喘患者治疗前后及30例健康查体者血清PDGF、foxp3和MMP-9，高分辨率CT(high resolution computed tomography，HRCT)行胸部检测。结果哮喘组血清中PDGF和MMP-9水平比健康对照组明显升高（P0.05），而foxp3明显降低（P0.01）。与治疗前相比哮喘组PDGF（P0.05）和MMP-9水平明显降低(P0.01)，但仍高于对照组；foxp3与对照组相比差异有统计学意义(P0.01)。HRCT结果显示，与对照组相比，哮喘组小支气管内径狭窄；小支气管内面积明显变小（P0.05)；小支气管外径无明显差异。治疗后小支气管管腔有明显扩张，面积明显增加(P0.01)；治疗前后小支气管对比外径无明显变化。结论哮喘患者有PDGF-foxp3和MMP-9的环路存在，综合治疗可以逆转气道重塑。

Abstract

Objective To study the relation between platelet-derived growth factor (PDGF)

foxp3

MMP-9 and airway remodeling due to asthma. Methods Serum PDGF

foxp3 and MMP-9 levels were measured in 40 patients with bronchial asthma (BA) and in 30 healthy controls before and after treatment by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Chest was detected by high resolution computed tomography (HRCT). Results The serum PDGF and MMP-9 levels were significantly higher while the serum foxp3 level was significantly lower in asthma patients than in healthy controls (P0.05). Although the serum PDGF and MMP-9 levels were significantly decreased in asthma patients after treatment

they were still higher than those in healthy controls (P0.05). HRCT showed that the inner diameter and area of bronchus were significantly smaller in asthma patients than in healthy controls (P0.05) with no significant difference in outer diameter of bronchus. The inner diameter of bronchus was remarkably dilated with its area notably increased with no significant difference in its outer diameter after treatment (P0.01). Conclusion There is a ring of PDGF

foxp3 and MMP-9 in asthma patients. Combined treatment can reverse the airway remodeling due to asthma.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Role of Foxp3 and regulatory T cells in pathogenesis of passive transferred myasthenia gravis in young mice

Changes of phenotype and function of human CD4⁺CD25^- T cells induced after Foxp3 transfection

Association between asthma and endocrine diseases: A Mendelian randomization study and mediation analysis

Features and clinical significance of airway microbiota in patients with neutrophilic asthma

Kinesin family member 3A is involved in inflammatory regulation of asthmatic airway epithelial by binding to β-arrestin in the Wnt/β-catenin pathway

Related Author

魏秀丽

黄志

李欣

刘玮

吴奎

毕玉田

王耀丽

王长征

Related Institution

Department of Respiratory Medicine， Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

⁰