Role of glutathione S-transferase genetic polymorphisms in persons with liver damage due to microcystin exposure

李砚; 陈济安; 赵清; 邱志群; 许川; 曾慧; 舒为群

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Role of glutathione S-transferase genetic polymorphisms in persons with liver damage due to microcystin exposure

更新时间：2026-01-09

- Role of glutathione S-transferase genetic polymorphisms in persons with liver damage due to microcystin exposure
- Journal of Army Medical University Vol. 32, Issue 21, Pages: 2322-2325(2010)
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  CLC： R123;R394.5R575
- Published：2010
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李砚,陈济安,赵清,邱志群,许川,曾慧,舒为群.谷胱甘肽转移酶基因多态性在微囊藻毒素致人群肝损伤发生中的作用[J].陆军军医大学学报(原第三军医大学学报),2010,32(21):2322-2325.

　Li Yan,Chen Jian,Zhao Qing,Qiu Zhiqun,Xu Chuan,Zeng Hui,Shu Weiqun.Role of glutathione S-transferase genetic polymorphisms in persons with liver damage due to microcystin exposure[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(21):2322-2325.
李砚,陈济安,赵清,邱志群,许川,曾慧,舒为群.谷胱甘肽转移酶基因多态性在微囊藻毒素致人群肝损伤发生中的作用[J].陆军军医大学学报(原第三军医大学学报),2010,32(21):2322-2325. DOI：

　Li Yan,Chen Jian,Zhao Qing,Qiu Zhiqun,Xu Chuan,Zeng Hui,Shu Weiqun.Role of glutathione S-transferase genetic polymorphisms in persons with liver damage due to microcystin exposure[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(21):2322-2325. DOI：

摘要

目的探讨谷胱甘肽转移酶（glutathione S-transferase

GST）M1（GSTM1）和T1（GSTT1）基因多态性在微囊藻毒素（microcystins，MCs）致人群肝损伤发生中的作用。方法在重庆涪陵区采用酶联免疫法检测饮用水和水产品中MCs浓度，并随机在MCs暴露人群中选择肝功异常人群81名，肝功正常人群92名为研究对象进行病例对照研究，多重PCR方法检测GSTM1和GSTTl基因多态性，采用χ

检验比较各组基因型的差异。结果饮用水中MCs的浓度连续4年超过国家规定标准，水产品中MCs阳性率为100%；GSTM1缺失频率在肝损伤组和对照组分别为43.2%和47.8%，两组间无显著统计学差异(P=1.00)；GSTT1缺失频率在肝损伤组为60.5%，高于对照组39.1%，两组间有显著统计学差异(P=0.006)；GSTM1和GSTT1共同缺失频率在肝损伤组为29.6%，同样高于对照组中16.3%，两组间有显著统计学差异（P=0.045）。结论 GSTT1缺失可能是在MCs暴露人群肝损伤的易感因素；GSTM1和GSTT1共同缺失将会增加MCs暴露人群发生肝损伤的危险性。

Abstract

Objective To study the role of genetic polymorphisms of glutathione Stransferases (GSTT1

GSTM1) in persons with liver damage due to microcystin (MC) exposure. Methods Concentrations of MC in drinking water and aquatic products in Fuling District (Chongqing

China) were measured by enzyme-linked immunosorbent assay

and 81 persons with liver damage were randomly selected as an observation group and 92 healthy persons served as a control group. Genetic polymorphisms of GSTM1 and GSTT1 were assayed by multiplex PCR. Difference in genotypes was detected by Chi square test. Results The concentration of MC in drinking water was higher than the national standard in the past 4 consecutive years

and the positive MC rate was 100% for aquatic products. The frequency of GSTM1 null genotype was 43.2% in observation group and 47.8% in control group (P0.05). The frequency of GSTT1 null genotype was 60.5% in observation group and 39.1% in control group (P0.05). The percentage of GSTM1 and GSTT1 null genotypes was 29.6% in observation group and 39.1% in control group (P0.05). Conclusion GSTT1 null genotype may be the susceptible factor for liver damage in persons exposed to MC. GSTM1 and GSTT1 null genotypes may increase the risk of developing liver damage in persons exposed to MC.

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