Effect of extensive small cell lung cancer metastasis on patient’s survival

李玮; 林萍; 王骐

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Effect of extensive small cell lung cancer metastasis on patient’s survival

更新时间：2026-01-09

- Effect of extensive small cell lung cancer metastasis on patient’s survival
- Journal of Army Medical University Vol. 32, Issue 17, Pages: 1861-1864(2010)
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  CLC： R73-37;R734.2;R195.4
- Published：2010
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李玮,林萍,王骐.广泛期小细胞肺癌转移状态对生存的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(17):1861-1864.

　Li Wei,Lin Ping,Wang Qi.Effect of extensive small cell lung cancer metastasis on patient’s survival[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(17):1861-1864.
李玮,林萍,王骐.广泛期小细胞肺癌转移状态对生存的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(17):1861-1864. DOI：

　Li Wei,Lin Ping,Wang Qi.Effect of extensive small cell lung cancer metastasis on patient’s survival[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(17):1861-1864. DOI：

摘要

目的回顾性分析广泛期小细胞肺癌患者转移状态对其生存的影响，以指导预后评估。方法 2003 年1 月至2008 年12 月收治134 例广泛期小细胞肺癌患者，采用Kaplan-Meier法及Cox回归模式来分析患者一般情况、局部受侵情况、远处转移部位、多器官联合转移状态、转移病灶数目等因素与生存的关系。结果单因素、多因素生存分析远处转移部位与生存密切相关：肝、骨髓转移者生存期最短，中位生存期5个月；而肺转移者中位生存期最长8个月，统计学分析有明显差异（P＜0.05）；患者一般情况如性别、年龄、一般状况评分、局部受侵情况如有无胸水、心包积液及上腔静脉压迫综合征等及多器官联合转移状态、转移病灶数目等因素与生存期无关(P0.05)。结论本组病例显示远处转移部位与广泛期小细胞肺癌患者生存相关。

Abstract

Objective　To retrospectively analyze the effect of extensive small cell lung cancer (SCLC) metastasis on survival of SCLC patients.　Methods　Kaplan-Meier method and Cox regression were used to analyze the relation between general condition

local invasion

distal metastasis

multiple organ metastasis

metastatic foci and survival of 134 patients with extensive SCLC metastasis

admitted to hospital from January 2003 to December 2008.　Results　Univariate analysis and multivariate analysis showed that the distal organ metastasis was closely related with the survival of patients with extensive SCLC metastasis (P＜0.05). The survival time of SCLC patients with liver and kidney metastasis was the shortest with a median survival time (MST) of only 5 month (RR=0.423)

while the MST of those with lung metastasis was 8 months (RR=-0.450

P0.05). The survival of SCLC patients was not related with their sex

age and general condition

local invasion (including pleural effusion and pericardial effusion)

superior vena cava compression syndrome

multiple organ metastasis

and metastatic foci.　Conclusion　The survival of SCLC patients is related with distal metastatic organs but not with the general condition

local invasion

multiple organ metastasis

and metastatic foci.

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