Expression and significance of lipid metabolism-related genes in breast invasive ductal carcinoma

吕静; 王斌; 糜漫天; 张乾勇; 朱俊东; 王建

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Expression and significance of lipid metabolism-related genes in breast invasive ductal carcinoma

更新时间：2026-01-09

- Expression and significance of lipid metabolism-related genes in breast invasive ductal carcinoma
- Journal of Army Medical University Vol. 32, Issue 12, Pages: 1290-1292(2010)
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  CLC： Q591.5;R349.3;R737.9
- Published：2010
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吕静,王斌,糜漫天,张乾勇,朱俊东,王建.脂质代谢相关基因在乳腺浸润性导管癌中的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2010,32(12):1290-1292.

　Lu Jing,Wang Bin,Mi Mantian,Zhang Qianyong,Zhu Jundong,Wang Jian.Expression and significance of lipid metabolism-related genes in breast invasive ductal carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(12):1290-1292.
吕静,王斌,糜漫天,张乾勇,朱俊东,王建.脂质代谢相关基因在乳腺浸润性导管癌中的表达及其意义[J].陆军军医大学学报(原第三军医大学学报),2010,32(12):1290-1292. DOI：

　Lu Jing,Wang Bin,Mi Mantian,Zhang Qianyong,Zhu Jundong,Wang Jian.Expression and significance of lipid metabolism-related genes in breast invasive ductal carcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(12):1290-1292. DOI：

摘要

目的观察乳腺浸润性导管癌组织和癌旁正常乳腺组织中脂质代谢调控基因的表达，并探讨其与乳腺浸润性导管癌发生的关系。方法收集30例乳腺浸润性导管癌患者手术切除的乳腺癌组织和癌旁乳腺组织，RT-PCR检测各组织中脂肪酸合成酶(fatty acid synthase

FAS)、环氧合酶(cyclooxygenase2

Cox-2)、5-脂氧合酶(5-lipoxygenase

5-LOX)及过氧化物酶增殖活化受体γ (peroxisome proliferatoractivated receptor γ

PPAR-γ)的基因表达。结果乳腺浸润性导管癌组织中FAS mRNA的表达显著高于癌旁组织(3.265±0.913 vs 1.300±0.712

P0.01)，同时乳腺癌组织中Cox-2、5-LOX mRNA的表达显著高于癌旁组织(2.449±1.333 vs 1.027±0.596

P0.05;2.766±1.193 vs 1.159±0.520

P0.05)，PPAR-γ mRNA的表达在乳腺癌组织和癌旁乳腺组织间差异无统计学意义(2.771±1.313 vs 2.235±1.383

P0.05)。 结论 FAS、Cox-2及5-LOX基因的高表达与乳腺浸润性导管癌的发生有关，提示脂质代谢途径调控对乳腺癌的预防具有重要的意义。

Abstract

Objective To investigate the expressions of lipid metabolism-related genes in breast invasive ductal carcinoma and adjacent non-cancerous tissues

and evaluate their roles in the occurrence of breast invasive ductal carcinoma. Methods Experimental samples were derived from our previous population study on breast cancer. Breast cancer tissues and adjacent non-cancerous tissues were spontaneously collected from 30 invasive ductal carcinoma patients. The expressions of fatty acid synthase (FAS)

cyclooxygenase-2 (Cox-2)

5-lipoxygenase (5-LOX) and peroxisome proliferator-activated receptor γ (PPAR-γ) mRNA were detected by RT-PCR. Results Expressions of FAS

Cox-2

and 5-LOX in breast cancer tissues were significantly higher than those in adjacent tissues (FAS: 3.265±0.913 vs 1.300±0.712

P0.01; Cox-2 and 5-LOX: 2.449±1.333 vs 1.027±0.596

P0.05; 2.766±1.193 vs 1.159±0.520

P0.05). There was no significant difference of PPAR-γ expression between the 2 groups (2.771±1.313 vs 2.235±1.383

P0.05). Conclusion Higher expressions of FAS

Cox-2

and 5-LOX are positively correlated with the occurrence of breast invasive ductal carcinoma.

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