Effect of pioglitazone on nerves of rats following traumatic brain injury

邓永兵; 唐文渊

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Effect of pioglitazone on nerves of rats following traumatic brain injury

更新时间：2026-01-09

- Effect of pioglitazone on nerves of rats following traumatic brain injury
- Journal of Army Medical University Vol. 32, Issue 15, Pages: 1638-1641(2010)
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  CLC： R-332;R651.15;R971
- Published：2010
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邓永兵,唐文渊.过氧化物酶体增殖物激活受体γ激动剂吡格列酮对大鼠创伤性脑损伤的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(15):1638-1641.

　Deng Yongbing,Tang Wenyuang.Effect of pioglitazone on nerves of rats following traumatic brain injury[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(15):1638-1641.
邓永兵,唐文渊.过氧化物酶体增殖物激活受体γ激动剂吡格列酮对大鼠创伤性脑损伤的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(15):1638-1641. DOI：

　Deng Yongbing,Tang Wenyuang.Effect of pioglitazone on nerves of rats following traumatic brain injury[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(15):1638-1641. DOI：

摘要

目的观察PPARγ激动剂吡格列酮对大鼠创伤性脑损伤的神经保护作用。方法将72只SD大鼠按随机数字表法分为假致伤组、对照组、吡格列酮治疗组，每组24只。采用改良的Feeney法制作脑创伤模型，治疗组采用吡格列酮（10 mg/kg）灌胃，假致伤组和对照组用等量生理盐水灌胃。致伤后在相应时相点行大鼠神经功能评分后，用干湿质量法进行脑组织含水量测定，进行HE、Nissl及TUNEL染色观察脑组织损伤、迟发性神经元死亡及神经细胞凋亡程度。结果 ①在伤后48 h、5 d，治疗组的神经功能评分[分别为（2.12±0.58）、（1.67±0.78）]好于对照组[(2.67±0.65)、（2.25±0.62）

P0.05]；②伤后24 h治疗组与对照组脑组织含水量差异无统计学意义[分别为（78.84±1.92）%、（79.21±2.20）%，P0.05]；③伤后48 h，治疗组迟发性神经元死亡(38.59±1.97)%和神经细胞凋亡数（31.67±4.76）明显低于对照组[分别为（51.25±4.01）%、（45.33±4.68）

P0.05]。结论 PPARγ激动剂吡格列酮能抑制创伤性脑损伤后的神经细胞凋亡，保护神经元，从而发挥神经保护作用。

Abstract

Objective To study the neural protective effect of pioglitazone

a peroxisome proliferator-activated receptor gamma (PPARγ) agonist

on nerves of rats following traumatic brain injury (TBI). Methods Seventy-two male Sprague-Dawley rats were randomly divided into pioglitazone treatment group

sham operation group

and control group (n=24 rats in each group). Rats in pioglitazone treatment received pioglitazone gastric perfusion (10 mg/kg) while rats in sham operation group underwent normal saline gastric perfusion (10 mg/kg). A rat model of brain injury was established with the Feeney’s free falling method. After neural function of rats was scored

water content in brain tissue was measured with the dry-wet weighing method. Injury of brain tissue

delayed death of neurons and apoptosis of nerve cells were observed with HE

TUNEL and Nissl’s staining

respectively. Results The neural function score was higher in pioglitazone treatment group than in control group in 48 h and 5 d after TBI (P0.05). No significant difference was found in brain tissue water content between pioglitazone treatment and control groups in 48 h after TBI [(78.84±1.92)% vs (79.21±2.20)%

P0.05]. The number of delayed dead and apoptotic nerve cells was significantly lesser in pioglitazone treatment group than in control group in 48 h after TBI (P0.05). Conclusion Pioglitazone can effectively inhibit the apoptosis of nerve cells

thus playing a role in protecting nerve cells of rats following TBI.

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