Development of CD1a<sup>+</sup>DC in human fetal platine tonsil

胡蓉; 苏敏; 黄悦; 李红; 姜俸蓉; 许庭良

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Development of CD1a⁺DC in human fetal platine tonsil

更新时间：2026-01-09

- Development of CD1a⁺DC in human fetal platine tonsil
- Journal of Army Medical University Vol. 32, Issue 17, Pages: 1854-1856(2010)
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  CLC： R329.1;R392.12;R322.42
- Published：2010
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胡蓉,苏敏,黄悦,李红,姜俸蓉,许庭良.CD1a+树突状细胞在胎儿腭扁桃体内的发育[J].陆军军医大学学报(原第三军医大学学报),2010,32(17):1854-1856.

　Hu Rong,Su Min,Huang Yue,Li Hong,Jiang Fengrong,Xu Tingliang.Development of CD1a+DC in human fetal platine tonsil[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(17):1854-1856.
胡蓉,苏敏,黄悦,李红,姜俸蓉,许庭良.CD1a+树突状细胞在胎儿腭扁桃体内的发育[J].陆军军医大学学报(原第三军医大学学报),2010,32(17):1854-1856. DOI：

　Hu Rong,Su Min,Huang Yue,Li Hong,Jiang Fengrong,Xu Tingliang.Development of CD1a+DC in human fetal platine tonsil[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(17):1854-1856. DOI：

摘要

目的探讨CD1a

树突状细胞(dendritic cell，DC)在胎儿腭扁桃体内的发育。方法收集9～28周因故终止妊娠胎儿腭扁桃体标本29例，用EnVision二步法染色显示CD1a

DC。结果 12周胎儿腭扁桃体，可见少量CD1a

DC，分布于隐窝上皮基底层和中间层，细胞体梭形或不规则形，由细胞体发出数根树枝样突起，细胞核圆形或卵圆形。14周胎儿腭扁桃体，CD1a

DC数量增加，隐窝上皮周围的固有层弥散淋巴组织内也可见CD1a

DC。16周胎儿腭扁桃体，表面上皮内可见CD1a

DC分布。17～24周胎儿腭扁桃体，随着CD1a

DC数量增多，在上皮浅层渐可见阳性细胞。28周胎儿腭扁桃体，淋巴小结内始见几个CD1a

DC聚集。细胞计数显示CD1a

DC数，9～12周胎儿腭扁桃体为（2.60±1.14）个，随胎龄增加至25～28周胎儿腭扁桃体达（57.20±6.06）个，任意胎龄组间比较具有显著性差异（P0.05）。结论 CD1a

DC 12周迁入胎儿腭扁桃体隐窝上皮，随后逐渐出现在固有层弥散淋巴组织、表面上皮以及淋巴小结内。 CD1a

DC数量随胎龄增长逐渐增多，主要分布于隐窝上皮内，固有层弥散淋巴组织和表面上皮内较少，淋巴小结内最少。

Abstract

Objective　To study the development of CD1a

DC in human fetal platine tonsil.　Methods　Twenty-nine cases of human fetal palatine tonsil were collected at gestational weeks 9-28. CD1a

DC were identified with EnVision double staining.　Results　A small number of CD1a

DC were detected at gestational week 12

which were distributed in basal lamina and stratum intermedium of crypt epithelium in human fetal

platine tonsil. The cell bodies were fusiform or irregular in shape with several tree branch-like eruptions derived from them. The cell nuclei were round or oval in shape. The number of CD1a

DC was increased at gestational week 14 with CD1a

DC observed in diffused lymphoid tissue around the crypt. CD1a

DC were distributed in surface epithelium at gestational week 16. Positive CD1a

DC were gradually observed in lamina superficialis of endepidermis due to the increased number of CD1a

DC from gestational weeks 17- 24. Several CD1a

DC began to emerge in lymphoid nodules at gestational week 28. The number of CD1a

DC was increased from 2.60±1.14 at gestational weeks 9-12 to 57.20±6.06 at gestational weeks 25-28 with the growth of fetal age (P0.05).　Conclusion　CD1a

DC are immigrated into the crypt epithelium of human fetal palatine tonsil at gestational week 12

and can be gradually observed in diffused lymphoid tissue

surface epithelium and lymphoid nodules. The number of CD1a

DC increases gradually with the growth of fetal age. CD1a

DC are mainly distributed in crypt epithelium

less in diffused lymphoid tissue and surface epithelium

and least in lymphoid nodules.

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Development of CD1a+DC in human fetal platine tonsil

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Development of CD1a⁺DC in human fetal platine tonsil