Expressions and significances of EMMPRIN, MMP-2, MMP-9 and VEGF in endometriosis

张婧; 唐良萏; 周敏; 龙行涛

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Expressions and significances of EMMPRIN, MMP-2, MMP-9 and VEGF in endometriosis

更新时间：2026-01-09

- Expressions and significances of EMMPRIN, MMP-2, MMP-9 and VEGF in endometriosis
- Journal of Army Medical University Vol. 32, Issue 12, Pages: 1278-1281(2010)
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  CLC： R711.71;R446.6;R34
- Published：2010
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张婧,唐良萏,周敏,龙行涛.细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶与血管内皮生长因子在子宫内膜异位症中的表达及意义[J].陆军军医大学学报(原第三军医大学学报),2010,32(12):1278-1281.

　Zhang Jing,Tang Liangdan,Zhou Min,Long Xingtao.Expressions and significances of EMMPRIN, MMP-2, MMP-9 and VEGF in endometriosis[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(12):1278-1281.
张婧,唐良萏,周敏,龙行涛.细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶与血管内皮生长因子在子宫内膜异位症中的表达及意义[J].陆军军医大学学报(原第三军医大学学报),2010,32(12):1278-1281. DOI：

　Zhang Jing,Tang Liangdan,Zhou Min,Long Xingtao.Expressions and significances of EMMPRIN, MMP-2, MMP-9 and VEGF in endometriosis[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(12):1278-1281. DOI：

摘要

目的探讨细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer，EMMPRIN)、基质金属蛋白酶2(matrix metalloproteinases 2，MMP-2)、基质金属蛋白酶9（MMP-9)和血管内皮生长因子（vascular endothelial growth factor，VEGF）在子宫内膜异位症(endometriosis

EM)中的表达及意义。方法应用免疫组化SABC三步法检测57例EM患者子宫内膜组织（57例异位内膜，51例在位内膜）和同期48例非EM患者的正常子宫内膜（对照组）中EMMPRIN、MMP-2、MMP-9及VEGF的表达情况，并对各蛋白表达水平进行相关性分析。结果 EMMPRIN、MMP-2、MMP-9及VEGF在EM异位内膜表达[分别为(0.723±0.114)、(0.729±0.109)、(0.692±0.089)、(0.704±0.103)]均高于EM在位内膜组[分别为(0.396±0.097)、(0.365±0.023)、(0.349±0.030)、(0.370±0.129）]（P0.05）；Pearson相关分析显示，在EM异位内膜中各蛋白表达呈显著正相关（P0.05）。在EM异位内膜组中EMMPRIN、MMP-2、MMP-9及VEGF表达Ⅲ～Ⅳ期[分别为(0.780±0.058)、（0.779±0.064）、（0.736±0.050）、（0.749±0.059）]高于Ⅰ～Ⅱ期[分别为（0.563±0.070）、（0.588±0.079）、（0.570±0.051）、（0.580±0.100）](P0.05)。MMP-2在EM在位内膜组表达较对照组高(P0.05)。结论 EMMPRIN、MMPs和VEGF在EM中高表达，EMMPRIN-MMPs-VEGF系统上调可能在EM异位内膜种植、侵袭中发挥重要作用。

Abstract

Objective To investigate the expressions and significances of extracellular matrix metalloproteinase inducer (EMMPRIN)

the matrix metalloproteinases-2

-9 (MMP-2

-9)

and the vascular endothelial growth factor (VEGF) in endometriosis (EM). Methods The expressions of the EMMPRIN

MMP-2

MMP-9 and VEGF were detected by SABC immunohistochemistry in 57 tissue samples of ectopic endometrium and 51 samples of eutopic endometrium obtained from 57 EM patients

and in 48 normal endometrium from patients with nonendometriosis. Correlation analysis was carried out on the expressions of these proteins and pathologic staging. Results The EMMPRIN

MMP-2

MMP-9 and VEGF in ectopic endometrium were expressed at significantly higher levels (0.723±0.114

0.729±0.109

0.692±0.089

0.704±0.103

respectively) than those in eutopic endometrium group (0.396±0.097

0.365±0.023

0.349±0.030

0.370±0.129

respectively

P0.05). Pearson correlation analysis showed that positive correlation were found between the EMMPRIN

MMP-2

MMP-9 and VEGF in ectopic endometrium group (P0.05). The expression levels of the EMMPRIN

MMP-2

MMP-9 and VEGF in the stages of Ⅲ to Ⅳ (0.780±0.058

0.779±0.064

0.736±0.050

0.749±0.059

respectively) were significantly higher than those in Ⅰ to Ⅱ (0.563±0.070

0.588±0.079

0.570±0.051

0.580±0.100

respectively) in ectopic endometrium group (P0.05). The MMP-2 in eutopic endometrium group had significantly higher levels than the control group (P0.05). Conclusion EMMPRIN

MMPs and VEGF are expressed highly in ectopic endometrium. The up-regulation of EMMPRIN-MMPs-VEGF system may play an important role in ectopic endometrium planting and invasion of EM.

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