Liu Hong,Liu Qing,Lei Han,Li Xiulan,Chen Xian.Inflammatory stress promotes lipid accumulation in aorta of scavenger double knockout mice[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(16):1728-1731.
Liu Hong,Liu Qing,Lei Han,Li Xiulan,Chen Xian.Inflammatory stress promotes lipid accumulation in aorta of scavenger double knockout mice[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(16):1728-1731.DOI:
Inflammatory stress promotes lipid accumulation in aorta of scavenger double knockout mice
SR DKO) C57BL/6J小鼠主动脉固醇调节元件结合蛋白2(sterol regulatory element binding protein2, SREBP2)表达,加重主动脉脂质异常积聚的分子机制。 方法 13只SR DKO雄性小鼠,按体质量大小,采用完全随机的方法,分为炎症组(n=6)和对照组(n=7)。喂养高脂饮食14周,检测血清炎症因子和脂质水平;油红O染色观察主动脉脂质积聚;实时定量PCR和免疫组织化学染色,分析主动脉低密度脂蛋白受体(LDLr)、调控其转录的SREBP2及SREBP2裂解激活蛋白(SCAP)mRNA和蛋白表达水平。 结果 炎症组血清淀粉样蛋白A(SAA)水平比对照组明显增高[(10.32±2.88)ng/ml vs (5.50±2.67)ng/ml,P0.05];主动脉切片油红O染色结果发现,炎症组比对照组脂质积聚明显增加;炎症组主动脉的SREBP2、SCAP和LDLr mRNA和蛋白表达水平比对照组明显增高(P0.05)。 结论 SR DKO小鼠在炎症状态下,促进主动脉胆固醇敏感器SCAP和SREBP2表达,上调LDLr,使胞内摄入胆固醇增加,加重主动脉脂质的异常积聚。
Abstract
Objective To investigate whether inflammatory stress exacerbates lipid accumulation and the mechanism of up - regulation of sterol regulatory element binding protein 2 (SREBP2) expression in the aorta of scavenger receptor double knockout (SR DKO) mice. Methods Male SR DKO mice fed with high lipid diet were randomly divided into the control group (
n
=7) and the inflammation group induced by 10% (w/v) 0 . 5 ml casein injection (
n
=6). After 14 weeks
the mice were sacrificed
and the blood
sample of right atrium was collected and the aorta was taken. Inflammatory cytokines
such as serum amyloid A (SAA)
IL - 6 and TNF - α was determined by ELISA. Serum levels of total cholesterol (TC) and low - density lipid cholesterol (LDL - C) were detected by enzymatic assay. Frozen sections of aorta were stained with Red Oil O to visualize lipid accumulation. Both the mRNA and protein expressions of SREBP2
SREBP cleavage - activating protein (SCAP) and low density lipoprotein receptor (LDLr) in the aorta were measured by real - time polymerase chain reaction and immunohistochemical staining respectively. Results Increased of serum SAA was observed in inflammatory mice (10.32 ± 2.88
vs
5.50 ± 2.67 ng/ml
P
0 . 05). In the inflammatory mice
a increase in SREBP2
SCAP and LDLr mRNA level of the aorta
as well as mature SREBP2
SCAP and LDLr proteins abundance were found
when compared with control animals (
P
0 . 05). Conclusion Inflammatory SR DKO mice are associated with increased SREBP2 gene expression of aortas. This is probably the cause for enhanced SCAP gene expression and
consequently
for increase cholesterol uptake through LDLr pathway and for promoting lipid accumulation in aortas of the mice with absence of uptake of modified LDL.