Value of point resolved spectrascopy and stimulated echo acquisition mode of <sup>1</sup>H-magnetic resonance in detection of multiple sclerotic foci in brain white matter with normal appearance

曾春; 李咏梅; 谢鹏; 吕发金; 罗天友; 陈璇; 王忠平

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Value of point resolved spectrascopy and stimulated echo acquisition mode of ¹H-magnetic resonance in detection of multiple sclerotic foci in brain white matter with normal appearance

更新时间：2026-01-09

- Value of point resolved spectrascopy and stimulated echo acquisition mode of ¹H-magnetic resonance in detection of multiple sclerotic foci in brain white matter with normal appearance
- Journal of Army Medical University Vol. 32, Issue 13, Pages: 1408-1412(2010)
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  CLC： R744.51;R445.2;R816.1
- Published：2010
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曾春,李咏梅,谢鹏,吕发金,罗天友,陈璇,王忠平.PRESS和STEAM波谱在多发性硬化病灶和看似正常表现脑白质区中的价值[J].陆军军医大学学报(原第三军医大学学报),2010,32(13):1408-1412.

　Zeng Chun,Li Yongmei,Xie Peng,Lu Fajin,Luo Tianyou,Chen Xuan,Wang Zhongping.Value of point resolved spectrascopy and stimulated echo acquisition mode of 1H-magnetic resonance in detection of multiple sclerotic foci in brain white matter with normal appearance[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(13):1408-1412.
曾春,李咏梅,谢鹏,吕发金,罗天友,陈璇,王忠平.PRESS和STEAM波谱在多发性硬化病灶和看似正常表现脑白质区中的价值[J].陆军军医大学学报(原第三军医大学学报),2010,32(13):1408-1412. DOI：

　Zeng Chun,Li Yongmei,Xie Peng,Lu Fajin,Luo Tianyou,Chen Xuan,Wang Zhongping.Value of point resolved spectrascopy and stimulated echo acquisition mode of 1H-magnetic resonance in detection of multiple sclerotic foci in brain white matter with normal appearance[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(13):1408-1412. DOI：

摘要

目的探讨长回波(echo time

TE)点分辨率波谱(point resolved spectroscopy

PRESS)和激励回波采集模式(stimulated echo acquisition mode

STEAM)2种2-D氢质子磁共振波谱(proton magnetic resonance spectroscopy

H-MRS)在多发性硬化(multiple sclerosis

MS)病灶及看似正常表现脑白质(normal appearing white matter

NAWM)中的价值。方法对56例复发-缓解型MS(relapsing-remitting MS

RRMS)患者和25例健康志愿者行常规磁共振成像(conventional magnetic resonance imaging

cMRI)扫描，并采用PRESSS长回波和STEAM短回波

H-MRS分析，测定各感兴趣区(region of interest

ROI)代谢物氮-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)、脂质(Lip)、乳酸(Lac)和肌醇(Ins)的浓度，分析NAA/Cr、Cho/Cr、NAA/Cho、Lac+Lip/Cr和Ins/Cr在病灶和NAWM区中的变化。结果 ① PRESS长回波显示NAA/Cr、Cho/Cr、NAA/Cho在急性病灶、慢性病灶和对照组相应脑白质(white matter

WM)区三者之间均有显著差异(P0.01)，NAA/Cr、NAA/Cho在急性病灶和慢性病灶间差异不显著(P0.05)；② STEAM短回波显示NAA/Cr、Cho/Cr和Lac+Lip/Cr在急性病灶、NAWM区和对照组相应WM区三者之间均有显著差异(P0.01)；③ 比较PRESS长回波和STEAM短回波对检测病灶平均代谢物的差异，结果示二者检测NAA/Cr和Cho/Cr无明显差别，但STEAM短回波更能检测到病灶内的Lip、Lac及Ins峰。结论 PRESS长回波和STEAM短回波能检测MS患者脑部病灶及NAWM区的代谢异常，但STEAM短回波较PRESS长回波能探测到更多代谢物。

Abstract

Objective

To study the value of long echo time (TE) point resolved spectroscopy (PRESS) and stimulated echo acquisition mode (STEAM) of

H-magnetic resonance in detection of multiple scleroses (MS) in brain white matter with a normal appearance. Methods Conventional magnetic resonance imaging was performed in 56 patients with relapsing-remitting MS (RRMS) and in 25 healthy volunteers. The results were analyzed using the long TE PRESS sequence and short TE STEAM sequence of

H- magnetic resonance. Concentrations of metabolic products

including N-acetylaspartic acid (NAA)

choline (Cho)

creatine (Cr)

lipid (Lip)

lactic acid (Lac)

and inositol (Ins)

were measured in each region of interest (ROI). Changes of NAA/Cr

Cho/Cr

Lip+Lac/Cr and Ins/Cr in MS and brain white matter with a normal appearance were analyzed. Results Long TE PRESS sequence showed that the NAA/Cr

Cho/Cr and NAA/Cho were significantly different in white matter with acute and chronic lesions or in white matter with a normal appearance (P0.01). No significant difference in NAA/Cr and NAA/Cho was observed in white matter with acute and chronic lesions (P0.05). Short TE STEAM sequence showed that the NAA/Cr

Cho/Cr and Lac+Lip/Cr were significantly different in white matter with acute lesions or with a normal appearance. Long TE PRESS sequence and short TE STEAM sequence had no significant difference in detecting NAA/Cr and Cho/Cr in MS (P0.05).However

short TE STEAM sequence was advantageous over long TE PRESS sequence in detecting the Lip

Lac and Ins peaks. Conclusion Both long TE PRESS and short TE STEAM sequence can detect abnormal metabolites in MS and in white matter with a normal appearance. However

STEAM can detect more metabolites than long TE PRESS.

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Related Author

丁爽

杜思霖

祝琦源

严子淳

李咏梅

曾春

欧阳羽

侯焕新

Related Institution

Department of Radiology

Chongqing Clinical Research Centre of Imaging and Nuclear Medicine

Department of Pathology， Daping Hospital， Army Medical University

Department of Radiology， the First Affiliated Hospital of Chongqing Medical University

Department of Radiology，First Affiliated Hospital， Army Medical University （Third Military Medical University）

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Value of point resolved spectrascopy and stimulated echo acquisition mode of 1H-magnetic resonance in detection of multiple sclerotic foci in brain white matter with normal appearance

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摘要

Abstract

关键词

Keywords

references

Value of point resolved spectrascopy and stimulated echo acquisition mode of ¹H-magnetic resonance in detection of multiple sclerotic foci in brain white matter with normal appearance