Applications of uniform design method in preparation of LIDA-PLGA sustained release nanospheres

赵先英; 刘毅敏; 肖湘; 刘海红; 粟永萍; 李明春

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Applications of uniform design method in preparation of LIDA-PLGA sustained release nanospheres

更新时间：2026-01-09

- Applications of uniform design method in preparation of LIDA-PLGA sustained release nanospheres
- Journal of Army Medical University Vol. 32, Issue 21, Pages: 2300-2302(2010)
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  CLC： R943;R944.9;R971.2
- Published：2010
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赵先英,刘毅敏,肖湘,刘海红,粟永萍,李明春.均匀试验设计在利多卡因缓释纳米微球制备中的应用[J].陆军军医大学学报(原第三军医大学学报),2010,32(21):2300-2302.

　Zhao Xianying,Liu Yimin,Xiao Xiang,Li Haihong,Su Yongping,Li Mingchun.Applications of uniform design method in preparation of LIDA-PLGA sustained release nanospheres[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(21):2300-2302.
赵先英,刘毅敏,肖湘,刘海红,粟永萍,李明春.均匀试验设计在利多卡因缓释纳米微球制备中的应用[J].陆军军医大学学报(原第三军医大学学报),2010,32(21):2300-2302. DOI：

　Zhao Xianying,Liu Yimin,Xiao Xiang,Li Haihong,Su Yongping,Li Mingchun.Applications of uniform design method in preparation of LIDA-PLGA sustained release nanospheres[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(21):2300-2302. DOI：

摘要

目的制备利多卡因载药微球，研究制备工艺参数对微球包封率和粒径的影响。方法采用均匀试验设计法，以利多卡因（lidocaine

LID）为模型药物，以药物包封率、微球粒径为评价指标，基材及其用量为因素和水平进行U

（8

）的实验，得出最佳制备工艺参数。结果制备LID-PLGA-Ns的优选条件为：主药与包材基质的质量比为1∶6、内水相的体积比为8∶2、分散剂浓度PVA为3.0%、超声乳化时间为6 min、搅拌速度为2 200（r/min），此时能得到包封率高、平均粒径小的载药微球。结论应用均匀试验设计建立的多元二次模型可以较好地预测药微球的基本特性。

Abstract

Objective To prepare the lidocaine-loaded nanospheres and study the effect of their pre-paration techniques on their drug encapsulation efficiency (DEE) and mean diameter (MD). Methods U

（8

）experiments were performed using the uniform design method for basic materials and their volume with the DEE and MD of nanospheres as evaluation indexes and lidocaine as a drug model. Then

optimal preparation technique parameters of nanospheres were detected. Results The optimal conditions for preparation of LID-PLGA nanospheres were as follows. The mass ratio of the main drug and its encapsulation substrate was 1∶6

the volume ratio of inner water phase was 8∶2

the concentration of PVA was 3.0%

the phacoemulsification time

was 6 min

and the stirring rate was 2 200 r/min. Conclusion Multiple secondary model established with uniform design method can rather accurately predict the basic characteristics of drug nanospheres.

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