Objective　To study the role of low density lipoprotein receptor-related proteins

CD36 and SR-A

in lipid-mediated renal injury.　Methods　Male mice with their ApoE/CD36/SR-A knocked out were randomly divided into common diet group and high fat diet group. Levels of serum amyloid A (SAA)

interleukin-6 (IL-6)

lipid and urinary protein were measured. Lipid deposit in renal tissues was detected by enzyme linked immunosorbent assay with oil red O staining. Periodic acid Schiff (PAS) reaction and Masson method were used to observed changes in kidney morphology. PCR

Western blot analysis and immunohistochemistry were used to measure levels of related factors in renal tissue.　Results　The levels of SAA (TC=51.96±5.60 mmol/L and LDL=16.79±4.80 mmol/L)

lipid deposit in renal tissue

and urinary protein (2.90±0.50 mg/ml) were significantly higher in high fat diet group than those (TC=18.11±3.07 mmol/L and LDL=3.27±1.79 mmol/L

1.85±0.18 mg/ml) in common diet group(P0.05). The expression levels of low density lipoprotein receptor-related proteins

type Ⅰ collagen protein

TGF-β

and fibronectin mRNA were significantly higher in high diet group than in common diet group (P0.05).　Conclusion　Low density lipoprotein receptor-related proteins may play a role in formation of foam cells in kidney and renal injury. However

CD36 and SR-A cannot explain the overall mechanism underlying the formation of foam cells in kidney.