Objective    To investigate the effects of the free radical scavenger

edaravone

on patients undergoing cardiac valve replacement under cardiopulmonary bypass (CPB).     Methods    Thirty patients

including 7 males and 23 females

at a mean age of 41.4±10.4 (23 to 63)

undergoing mitral or/and aortic valve replacement (MVR or AVR) under CPB from March to December 2009 in our hospital were subjected

and then divided into 2 matched groups by means of random number table

study group (n=14) and control group (n=16)．Inclusion criteria: patients received valve replacement surgery under CPB; aging from 20 to 65; heart function: class Ⅰto Ⅲ; liver

kidney and lung function properly; blood gas and electrolyte properly. Exclude criteria: preoperatively used scavenger and the like; there was a history of cerebrovascular or neuropsychiatric symptoms; had a history of myocardial infarction or other coronary artery disease. In the intervention group

0.5 mg/kg of edaravone was diluted to 20 ml and introduced into CPB unit at the beginning

while the same dose of saline water was given in control group in the same way. Blood samples were collected from radial artery at following 5 time points

the beginning of CPB (T

0

)

the end of CPB (T

1

)

30 min (T

2

)

6 h (T

3

)

and 24 h (T

4

) after CPB. After the blood samples of all cases were collected

the serum level of hematocrit (HCT)

malondialdehyde (MDA)

inducible nitric oxide synthase (iNOS)

cardiac troponin I (cTnI)

creatine kinase-MB (CK-MB)

myoglobin (Myo)

S100 protein and neuronspecific enolase (NSE) was detected. Cardiac resuscitation and critically postoperative complications were observed.     Results    The level of HCT at T

1

-T

3

cTnI at T

4

was lower in study group than that in control (P0.05). There was no obvious difference in MDA

iNOS

CK-MB

Myo

NSE and S100 protein between 2 groups at all 5 time points (P0.05). There was also no obvious difference in the indexes of cardiac resuscitation between 2 groups (P0.05). One case was found to have acute kidney failure in study group.     Conclusion    There is no obvious cardiocerebral protective effect of edaravone in cardiac

valve replacement surgery under CPB

and is even accompanied by some complications

such as acute kidney failure

erythrocytes decrease

and so on.