Objective　To explore the changes of the Klotho protein expression in blood serum of hypertensive patients with brain harm

so as to investigate the incidence mechanism of brain harm caused by hypertension and the associated risk factors. 　Methods　The research objects were recruited from the hypertensive in-patients and healthy individuals from health examination during September 2007 to March 2008 in our hospital. There were 56 hypertensive patients without syndrome

104 hypertensive patients with brain harm

and 30 normal control individuals

They all were marched in sex and age. Klotho protein concentration of blood serum

cholesterin

creatinine

blood glucose and blood pressure of these 3 groups were tested. And correlation analysis of the above factors and the patients’ ages and hypertension medical records was performed. 　Results　The Klotho protein concentration of blood serum in the normal control group was obviously higher than that of the hypertensive patients without syndrome and those with brain harm (P0.05）; The Klotho protein concentration of blood serum of the hypertensive patients without syndrome was obviously higher than that of the hypertensive patients with brain harm (P0.05）. The Klotho protein concentration of blood serum was negatively pertinent with hypertension and the cholesterol

creatinine

blood glucose

blood pressure

age

sex and hypertension medical record of the hypertensive patient with brain harm. The higher the cholesterol

creatinine

blood glucose and blood pressure was

the older the age was

and the longer hypertension medical record was

the lower the Klotho protein concentration of blood serum was. 　Conclusion　The increase of the Klotho protein concentration might be a protective factor of hypertension and brain harm caused by hypertension. In order to monitor and prevent brain harm caused by hypertension at the early stage

it is beneficial for the hypertensive patient to have a test of the Klotho protein concentration of blood serum regularly.