Epidemiology and drug resistance of fungal infection during early postoperative period in liver transplantation: an analysis of 26 cases

郑志鹏; 周杰

您当前的位置：

首页 >

文章列表页 >

Epidemiology and drug resistance of fungal infection during early postoperative period in liver transplantation: an analysis of 26 cases

更新时间：2026-01-09

- Epidemiology and drug resistance of fungal infection during early postoperative period in liver transplantation: an analysis of 26 cases
- Journal of Army Medical University Vol. 32, Issue 10, Pages: 1106-1108(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R372;R617;R657.3
- Published：2010
- 稿件说明：
移动端阅览
郑志鹏,周杰.26例肝移植术后早期真菌感染患者的真菌类型及耐药性分析[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1106-1108.

　Zheng Zhipeng,Zhou Jie.Epidemiology and drug resistance of fungal infection during early postoperative period in liver transplantation: an analysis of 26 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1106-1108.
郑志鹏,周杰.26例肝移植术后早期真菌感染患者的真菌类型及耐药性分析[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1106-1108. DOI：

　Zheng Zhipeng,Zhou Jie.Epidemiology and drug resistance of fungal infection during early postoperative period in liver transplantation: an analysis of 26 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1106-1108. DOI：

摘要

目的探讨肝移植术后早期真菌感染的流行病学特点及耐药特性。方法回顾性分析本院2004年8月至2009年1月所施行的118例肝移植患者中真菌感染病例，通过真菌培养鉴定及药敏试验分析真菌感染特点。结果 26例发生真菌感染，患病率为22.0%。感染部位主要发生在呼吸道（75.5%），共分离出49株真菌，以白色念珠菌为主（57.1%），曲霉菌、光滑念珠菌、热带念珠菌、近平滑念珠菌、克柔念珠菌的检出率分别为18.4%、10.2%、6.1%、4.1%、4.1%。药敏试验显示药物敏感率从高到低依次为伏立康唑、伊曲康唑、两性霉素B、氟胞嘧啶、氟康唑，分别为92.0%、90.0%、75.5%、73.5%、55.1%。结论肝移植术后真菌感染主要是白色念珠菌，氟康唑的总体敏感性较低，临床上应加强肝移植术后患者真菌的鉴定和耐药监测，合理选用抗真菌药物。

Abstract

Objective To investigate the epidemiology and drug resistance associated with fungal infection during early postoperative period after liver transplantation in the purpose of prevention and treatment. Methods A total of 118 cases of liver transplantation admitted from April 2004 to January 2009 in Nanfang Hospital were studied retrospectively

and the fungal infection and drug resistance were identified. Results Fungal infections occurred in 26 cases (22.0%). Totally there were 49 fungi strains isolated

of which mainly Candida albicans (57.1%)

followed by Aspergillus (18.4%)

Smooth Candida (10.2%)

Candida tropicalis (6.1%)

Candida parapsilosis (4.1%)

and Candida krusei (4.1%). The sensitive rate of voriconazole

itraconazole

amphotericin B

5-fluorouracil

fluconazole were 92.0%

90.0%

75.5%

73.5%

and 55.1% respectively. Conclusion Because of the change of fungi strains and the increase of drug resistance

it’s important to identify the fungi and drug resistance for the purpose of prophylaxis and treatments.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Achievements and challenges: Key priorities for prevention and control in the elderly amid the declining disease burden of benign prostatic hyperplasia in China

Predictive performance of CT images-based 3D ResNet18 model for identifying lung tuberculosis drug resistance

Epidemiological characteristics and trends of primary intussusception among children in Wuhan from 2016 to 2022

LINC00525 targeting miR-338-3p promotes apoptosis and reduces paclitaxel resistance in gastric cancer cells

Analysis of copy number variation in pfpm2 gene of Plasmodium falciparum in 122 imported cases in Changsha from 2016 to 2019

Related Author

ZHANG Bowen

LIU Yunlong

DING Mengdi

ZHAO Ying

ZHAO Yu

LIU Xiaomei

FANG Kai

LI Meng

Related Institution

Center for Clinical Pharmacology

Department of Urology， the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine

Department of Urology， Xiyuan Hospital， China Academy of Chinese Medical Sciences

Department of Andrology， the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine， National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion

Department of Medical Imaging， Chongqing Public Health Medical Center

⁰