Objective   To detect the expression of syntenin in human gliomas and evaluate the relationship between its expression and the tumor grades.    Methods   Clinical data of 34 cases pathologically verified human glioma

including 19 males and 15 females

with an age ranging from 17 to 68 (mean 43) were analyzed retrospectively. The tumors were pathologically categorized and graded according to WHO classification of tumours of the central nervous system 2007. The expression of syntenin protein in these tumor tissues were detected by immunohistochemical staining and Western blot analysis. The results were compared with different glioma grades and pathological differentiation.    Results   The positive expression cells were detected scatteredly in normal brain tissue

while not in human glioma of WHO-Ⅰ by immunohistochemistry. The number of the positive cells was increased and the staining became stronger in the tissue with the human glioma of WHO-Ⅱ

WHO-Ⅲ and WHO-Ⅳ in turn.  Image analysis showed that there were more syntenin expressed with the increase of tumor grade

with significant difference with that of normal brain tissue (P0.05) . The expression of syntenin was positively correlated with tumor grade (r=0.896

P0.05) . The glioma tissue of  WHO-Ⅰhad no positive band detected

while there were more syntenin expression in the glioma of WHO-Ⅱ

WHO-Ⅲ and WHO-Ⅳ in turn

with significantly differences (P0.05) .    Conclusion   The expression of syntenin has a significant correlation with glioma grades

which maybe play an important role in the progress of the human glioma.