Expression and significance of human defensin-alpha1-3 in breast cancer

张伟; 顾敏

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Expression and significance of human defensin-alpha1-3 in breast cancer

更新时间：2026-01-09

- Expression and significance of human defensin-alpha1-3 in breast cancer
- Journal of Army Medical University Vol. 32, Issue 10, Pages: 1064-1067(2010)
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  CLC： {R392.13};R730.23;R737.9
- Published：2010
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张伟,顾敏.人防御素-alpha1-3在乳腺癌组织中的表达及意义[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1064-1067.

　Zhang Wei,Gu Min.Expression and significance of human defensin-alpha1-3 in breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1064-1067.
张伟,顾敏.人防御素-alpha1-3在乳腺癌组织中的表达及意义[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1064-1067. DOI：

　Zhang Wei,Gu Min.Expression and significance of human defensin-alpha1-3 in breast cancer[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1064-1067. DOI：

摘要

目的探讨人防御素-alpha1-3（HNP1-3）在乳腺癌组织中的表达及其临床意义。方法采用免疫组化法检测20例乳腺组织及59例乳腺癌组织中HNP1的表达，并结合乳腺癌患者年龄、临床分期、组织学分级、淋巴结转移以及PR/ER/C-erB-2表达进行相关性分析。结果 ①HNP1-3在正常乳腺组织中为强阳性表达，表达率为95%；②HNP1-3在癌组织中差异表达，在淋巴结转移患者的强阳性表达为45%，而淋巴结未转移患者表达强阳性率81.08%（P0.05），强阳性率在组织学Ⅰ级为85.71%，Ⅱ级72.22%，Ⅲ级45%（P0.05）；③HNP1-3在乳腺癌中的表达与肿瘤患者年龄、临床分期、PR/ER/C-erB-2表达无显著差异（P0.05）。结论 HNP1-3在乳腺癌的发展过程中起重要作用，其表达水平可能是反映乳腺癌预后的标记。

Abstract

Objective To investigate the expression of human defensin-alpha1-3 (HNP1-3) in breast cancer and in normal tissues and determine whether there exists a relationship between HNP1-3 expression and clinicopathologic features. Methods Immunohistochemical staining was used to detect the expression levels of HNP1-3 in 59 breast cancer specimens

and 20 normal tissues (fibroadenoma of breast or tumor-adjacent tissues). The relationship of the expression levels of HNP1-3 with patient’s age

clinical stage

histological grade

lymph node metastases and expression of PR/ER/C-erB-2 was analyzed. Results High level expression of HNP1-3 (95%) was expressed in those normal breast tissues. Different expression of HNP1-3 was found in breast cancer specimens and closely correlated with tumor histological stage and lymph node metastases (P0.05). There was no relation with ages

clinical stage and expression of PR/ER/C-erB-2 (P0.05). Conclusion HNP1-3 may play an important role in the pathogenesis of breast cancer

and regard as a biomarker for prognosis.

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Related Institution

Department of Breast and Thyroid Surgery， First Affiliated Hospital， Army Medical University （Third Military Medical University）

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