Relationship of HDGF or VEGF expression with hepatocellular carcinoma angiogenesis: report of 108 cases

郑璐; 梁平; 李靖; 杨彤翰; 李洪艳; 黄小兵; 韩克强

您当前的位置：

首页 >

文章列表页 >

Relationship of HDGF or VEGF expression with hepatocellular carcinoma angiogenesis: report of 108 cases

更新时间：2026-01-09

- Relationship of HDGF or VEGF expression with hepatocellular carcinoma angiogenesis: report of 108 cases
- Journal of Army Medical University Vol. 32, Issue 7, Pages: 680-683(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.7;R73-37;R730.23
- Published：2010
- 稿件说明：
移动端阅览
郑璐,梁平,李靖,杨彤翰,李洪艳,黄小兵,韩克强.HDGF、VEGF在人肝细胞癌中的表达及其与肿瘤血管生成的关系[J].陆军军医大学学报(原第三军医大学学报),2010,32(07):680-683.

　Zheng Lu,Liang Ping,Li Jing,Yang Tonghan,Li Hongyan,Huang Xiaobing,Han Keqiang.Relationship of HDGF or VEGF expression with hepatocellular carcinoma angiogenesis: report of 108 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(07):680-683.
郑璐,梁平,李靖,杨彤翰,李洪艳,黄小兵,韩克强.HDGF、VEGF在人肝细胞癌中的表达及其与肿瘤血管生成的关系[J].陆军军医大学学报(原第三军医大学学报),2010,32(07):680-683. DOI：

　Zheng Lu,Liang Ping,Li Jing,Yang Tonghan,Li Hongyan,Huang Xiaobing,Han Keqiang.Relationship of HDGF or VEGF expression with hepatocellular carcinoma angiogenesis: report of 108 cases[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(07):680-683. DOI：

摘要

目的探讨肝癌衍生生长因子（hepatoma-derived growth factor，HDGF）、血管内皮生长因子（vascular endothelial growth factor，VEGF）在人肝细胞癌组织中的表达与肿瘤组织微血管形成过程之间的关系和临床意义。方法对108例人肝细胞肝癌及相应的癌旁肝组织标本进行了HDGF、VEGF和CD34免疫组织化学EnVision

法检测，并初步分析结果。结果 HDGF、VEGF在肝癌组织中阳性表达率分别为63.2%、69.1%；癌旁组织中阳性率分别为16.7%、20.3%。肝癌组织中HDGF、VEGF的表达呈正相关（P0.05），且两者共同阳性表达与肿瘤微血管密度（microvessel density，MVD）值之间呈正相关（r=0.728

P0.01；r=0.608，P0.05）。结论肝癌组织中异常表达增高的HDGF、VEGF与肝癌微血管形成过程相关，可作为判断肝细胞癌侵袭能力、血管生成、判断患者预后的参考标志。

Abstract

Objective To investigate the relationship between the expression of hepatomaderived growth factor (HDGF) or vascular endothelial growth factor (VEGF) and angiogenesis of hepatocellular carcinoma (HCC) and its significance. Methods The expressions of HDGF and VEGF in 108 specimens of HCC and in their adjacent liver tissues were detected with EnVision

immunohistochemistry. Tumor microvessel density (MVD) was evaluated using CD34 antibody as an endothelial marker with the same technique as well. Results Positive rates of HDGF (63.2%) and VEGF expressions (69.1%) were s

ignificantly higher in HCC tissues than those in the adjacent liver tissues (16.7% and 20.3% respectively). Positive rates of HDGF and VEGF expressions in the HCC tissues were positively correlated (P0.05). The mean value of MVD was significantly higher in HCC tissues than in the adjacent liver tissues. Both HDGF and VEGF expressions were positively correlated with MVD value (r=0.728

P0.01

r=0.608

P0.05). Conclusion Overexpression of HDGF and VEGF are involved in the angiogenesis of HCC

and may be regarded as markers for invasion

angiogenesis

metastasis and prognosis of hepatocellular carcinoma.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression of cathepsin L in hepatocellular carcinoma

ETS1 transcription up-regulates FBXO45 and promotes invasion and migration of hepatocellular carcinoma via epithelial-mesenchymal transition

miR-576-5p regulates the EMT process to inhibit migration and invasion of hepatocellular carcinoma cells

Bilirubin impairs the sorafenib sensitivity in Huh7 cells through fatty acid oxidation by up-regulating PPARα/CPT1A

HBx promotes liver tumor in mice by inhibiting microRNA-145a-5p

Related Author

晋云

董家鸿

ZHU Zhenbao

WU Feifan

GU Yongpeng

XIE Chuanming

ZHANG Leida

崔琦

Related Institution

Department of Hepatobiliary Surgery， First Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Hepatobiliary Surgery， the Second Affiliated Hospital of Chongqing Medical University

⁰