Objective  To study the inhibitory effect of radicamine A on α-glucosidase and the glucose’s  absorption by small intestine.   Methods  Inhibitory effect of radicamine A was studied both in α-glucosidase inhibition experiments and by a valgus cyst model of small in testine in vitro.   Results  Radicamine A inhibited αglucosidase and glucose’s absorption in a dose-dependent manner (P0.01) and its IC

50

value was 2.27 mg/L and 0.10 mg/ml

respectively. No significant difference was observed in the inhibitory effects of acarbose and radicamine A on the glucose’s absorption in small intestine.   Conclusion  Radicamine A can significantly inhibit the glucose absorption in small intestine and can thus be expected to be

come a novel drug of diabetes.