Changes of plasma ET-1, CGRP, TXA<sub>2</sub> and their receptor expression in lung tissue of children with congenital heart disease-associated pulmonary artery hypertension

蔡宇红; 孙国成; 毛云英; 李宏

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Changes of plasma ET-1, CGRP, TXA₂ and their receptor expression in lung tissue of children with congenital heart disease-associated pulmonary artery hypertension

更新时间：2026-01-09

- Changes of plasma ET-1, CGRP, TXA₂ and their receptor expression in lung tissue of children with congenital heart disease-associated pulmonary artery hypertension
- Journal of Army Medical University Vol. 32, Issue 3, Pages: 253-256(2010)
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  CLC： R446.11;R725.411;R725.44
- Published：2010
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蔡宇红,孙国成,毛云英,李宏.先天性心脏病肺动脉高压患儿血浆ET-1、CGRP、TXA2及肺组织中其受体的变化[J].陆军军医大学学报(原第三军医大学学报),2010,32(03):253-256.

　Cai Yuhong,Sun Guocheng,Mao Yunying,Li Hong.Changes of plasma ET-1, CGRP, TXA2 and their receptor expression in lung tissue of children with congenital heart disease-associated pulmonary artery hypertension[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(03):253-256.
蔡宇红,孙国成,毛云英,李宏.先天性心脏病肺动脉高压患儿血浆ET-1、CGRP、TXA2及肺组织中其受体的变化[J].陆军军医大学学报(原第三军医大学学报),2010,32(03):253-256. DOI：

　Cai Yuhong,Sun Guocheng,Mao Yunying,Li Hong.Changes of plasma ET-1, CGRP, TXA2 and their receptor expression in lung tissue of children with congenital heart disease-associated pulmonary artery hypertension[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(03):253-256. DOI：

摘要

目的探讨左向右分流型先天性心脏病合并肺动脉高压患儿血浆内皮素-1(ET-1)、降钙素基因相关肽(CGRP)及血栓素A

(TXA

)的变化及其受体在肺组织中的变化。方法采集60例左向右分流型先天性心脏病患儿血浆，采用酶免、放射性免疫及ELISA等方法测定ET-1、CGRP和TXB

量，修补术中取患儿肺组织，采用RTPCT的方法检测相应受体在肺组织中的表达变化。结果与对照组相比，观察组(先天性心脏病组)患儿血浆ET-1及TXB

的水平明显增高(P0.05)，而血浆CGRP的含量水平则明显降低(P0.01)；与无肺动脉高压组患儿相比中、重度肺动脉高压患儿血浆ET-1和TXB

的含量显著增高，而CGRP的含量则显著降低(P0.05，P0.01)；经过PGE

治疗14 d后，患儿血浆ET-1和TXB

的含量显著降低(P0.01)，而CGRP的含量则无明显变化(P0.05)。与无肺动脉高压组患儿相比合并肺动脉高压患儿肺组织中ET-1和TXA

受体的mRNA表达显著增高，而CGRP受体的mRNA表达量则显著降低(P0.05，P0.01)。结论 ET-1、CGRP和TXA

与左向右分流型先天性心脏病合并肺动脉高压的发生与发展有着密切的联系，且测定这些指标可以用来判断其预后。

Abstract

Objective To study the changes of plasma ET-1

CGRP

TXA

and their receptor expression in lung tissue of children with congenital heart diseaseassicated pulmonary artery hypertension. Methods Plasma was collected from 60 children patients. ET-1

CGRP and TXB

levels were measured by

EIA

RIA and ELISA

respectively. Expression of their receptors in the lung tissue was detected by RT-PCR. Results The plasma ET-1 and TXB

levels were significantly higher in CHD patients than in control children. The plasma CGRP level was significantly lower in CHD patients than in control children. Fourteen days after treatment with PGE1

the plasma ET-1 and TXB

levels were significantly decreased with no significant changes in CGRP. The expression level of ET-1 and TXA

receptor mRNA was significantly higher in patients with pulmonary artery hypertension than in those without pulmonary artery hypertension. However

the expression of CGRP receptor mRNA was lower in patients with pulmonary artery hypertension than in those without pulmonary artery hypertension. Conclusion Plasma ET-1

CGRP and TXA

levels are closely related with congenital heart disease associated pulmonary artery hypertension

and can be used as an index for its prognosis.

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Changes of plasma ET-1, CGRP, TXA2 and their receptor expression in lung tissue of children with congenital heart disease-associated pulmonary artery hypertension

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摘要

Abstract

关键词

Keywords

references

Changes of plasma ET-1, CGRP, TXA₂ and their receptor expression in lung tissue of children with congenital heart disease-associated pulmonary artery hypertension