Expression of programmed death receptor-ligand 1 in human cervical carcinoma and its correlation with tumor infiltrating T cells

王渝琦; 徐光旭; 耿卫朴; 唐均英; 徐曼

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Expression of programmed death receptor-ligand 1 in human cervical carcinoma and its correlation with tumor infiltrating T cells

更新时间：2026-01-09

- Expression of programmed death receptor-ligand 1 in human cervical carcinoma and its correlation with tumor infiltrating T cells
- Journal of Army Medical University Vol. 32, Issue 11, Pages: 1173-1176(2010)
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  CLC： R737.33;R392.11;R392.3
- Published：2010
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王渝琦,徐光旭,耿卫朴,唐均英,徐曼.人子宫颈癌PD-L1的表达及其与肿瘤内浸润T细胞的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(11):1173-1176.

　Wang Yuqi,Xu Guangxu,Geng Weipu,Tang Junying,Xu Man.Expression of programmed death receptor-ligand 1 in human cervical carcinoma and its correlation with tumor infiltrating T cells[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(11):1173-1176.
王渝琦,徐光旭,耿卫朴,唐均英,徐曼.人子宫颈癌PD-L1的表达及其与肿瘤内浸润T细胞的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(11):1173-1176. DOI：

　Wang Yuqi,Xu Guangxu,Geng Weipu,Tang Junying,Xu Man.Expression of programmed death receptor-ligand 1 in human cervical carcinoma and its correlation with tumor infiltrating T cells[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(11):1173-1176. DOI：

摘要

目的观察负性免疫调节分子程序性死亡配体1（programmed death receptor-ligand 1，PD-L1）在人子宫颈癌的表达及其与肿瘤内T淋巴细胞浸润的关系。方法免疫组织化学染色观察5例正常宫颈组织、7例高级别宫颈上皮内瘤变（cervical intraepithelial neoplasia，CINⅡ-Ⅲ）组织和67例子宫颈癌组织中PD-L1的表达和淋巴细胞PD-1的表达，免疫荧光染色观察相应组织内浸润的CD4

T和CD8

T细胞数量，TUNEL法检测淋巴细胞凋亡。结果正常子宫颈上皮不表达PD-L1；宫颈瘤变上皮不表达或弱阳性表达PD-L1，70%（47/67）的宫颈癌表达PD-L1。肿瘤内浸润的部分淋巴细胞表达PD-1。子宫颈瘤变上皮与子宫颈鳞状细胞癌PD-L1表达存在明显差异（P0.01），浅表浸润的子宫颈鳞状细胞癌PD-L1 的表达略低于深部浸润的鳞状细胞癌，但无显著差异；PD-L1阳性病例肿瘤局部CD8

T细胞数量显著减少，且PD-L1 表达与CD8

T细胞数量明显负相关（r=-0.82，P0.01），但与肿瘤局部CD4

T细胞数量无明显相关性（r=-0.05，P0.05）；部分PD-L1阳性的子宫颈癌局部浸润的淋巴细胞存在凋亡现象。结论子宫颈癌细胞表达PD-L1，且PD-L1的表达与肿瘤局部浸润的CD8

T细胞数量减少有关，但与浸润的CD4

T细胞数量无关。癌细胞表达PD-L1可能促进了肿瘤内浸润的淋巴细胞凋亡。

Abstract

Objective To observe the expression of programmed death receptor-ligand 1 (PD-L1) in human cervical carcinoma and its correlation with tumor T cell infiltration. Methods Expression of PD-L1 and PD-1 was detected in 5 normal cervical tissue samples，7 high-level cervical intraepithelial neoplasia (CI

N Ⅱ-Ⅲ) tissue samples and 67 cervical carcinoma tissue samples

respectively

with immunohistochemistry staining. The number of tumor infiltrating CD4

T and CD8

T cells was counted with immunofluorescent staining. Apoptotic tumor infiltration lymphocytes were examined by TUNEL assay. Results PD-L1 was not expressed in normal cervical epithelium and negatively or weakly expressed in cancerous cervical epithelium. PD-L1 was expressed in 70% (47/67) of cervical carcinoma tissue samples. PD-1 was expressed in partial tumor infiltrating lymphocytes (P0.01). The expression level of PD-L1 was slightly lower in superficial invasive cervical carcinoma tissue samples than in deep invasive carcinoma tissue samples. The number of CD8

T cells was significantly decreased in patients with positive PD-L1.The expression of PD-L1 was negatively correlated with the number of tumor infiltrating CD8

T cells (r=-0.82，P0.01) but not with the number of CD4

T cells (r=-0.05，P 0.05). Apoptosis occurred in partial tumor infiltrating lymphocytes of cervical carcinoma tissue samples. Conclusion PD-L1 is expressed in cervical carcinoma cells. The expression of PD-L1 is correlated with the reduced number of tumor infiltrating CD8

T cells but not with the number of CD4

T cells. PD-L1 expression in tumor cells may play role in apoptosis of tumor infiltrating lymphocytes.

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