Expression of BAT2L protein in developmental brain of rats

刘运来; 李红丽; 孙榆; 罗雪; 董家鸿

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Expression of BAT2L protein in developmental brain of rats

更新时间：2026-01-09

- Expression of BAT2L protein in developmental brain of rats
- Journal of Army Medical University Vol. 32, Issue 9, Pages: 922-925(2010)
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  CLC： R322.81;R329.26;R341
- Published：2010
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刘运来,李红丽,孙榆,罗雪,董家鸿.BAT2L蛋白在大鼠脑内的发育学表达研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(09):922-925.

　Liu Yunlai,Li Hongli,Sun Yu,Luo Xue,Dong Jiahong.Expression of BAT2L protein in developmental brain of rats[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(09):922-925.
刘运来,李红丽,孙榆,罗雪,董家鸿.BAT2L蛋白在大鼠脑内的发育学表达研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(09):922-925. DOI：

　Liu Yunlai,Li Hongli,Sun Yu,Luo Xue,Dong Jiahong.Expression of BAT2L protein in developmental brain of rats[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(09):922-925. DOI：

摘要

目的检测BAT2L蛋白在大鼠脑内的发育学表达情况。方法分别采用Western blot、免疫组化、免疫荧光技术检测BAT2L蛋白在胚胎18 d，出生1、7、15 d，成年不同时期大鼠脑内的表达、分布、定位情况。结果 ①Western blot结果显示，BAT2L在胚胎18 d，出生1、7 d大鼠脑内有高水平表达，而出生15 d和成年则表达水平较低。②免疫组化、免疫荧光检测其在大鼠脑内的分布、定位情况：结果显示脑内阳性着色部位为神经元的细胞膜、细胞质，而细胞核、细胞外间质不着色；阳性神经元广泛分布于各个时期的大鼠大脑皮质、小脑皮质、海马、丘脑等部位；阳性神经元的形态在新生阶段和成年大鼠有明显差异

新生大鼠脑组织中部分神经元的突起及分支呈强阳性着色，而成年大鼠神经元突起几乎不着色。结论 BAT2L蛋白特异性表达于大鼠大脑的神经元胞体、胞膜及突起中。

Abstract

Objective To detect the expression of BAT2L protein in developmental brain of rats. Methods Expression

distribution and location of BAT2L protein in developmental brain rats on embryonic day 18，postnatal days 1

7 and 15 and in adult at different time points were detected by Western blotting analysis

immunohistochemistry and immunofluorescence

respectively. Results Western blotting showed that the BAT2L protein expression level was higher in brain of rats on embryonic day 18

postnatal days 1 and 7 than on postnatal day 15 and in brain of adult rats. Immunohistochemistry and immunofluorescence showed that the BAT2L protein was distributed and located in cell membrane and cytoplasm of neurons but not in nuclei and extra-cellular space. Positive neurons were widely distributed in cerebral and cerebellar cortex

hippocampus and cerebral ganglion. The morphology of neurons was significantly different in newborn and adult rats. Positive prominences and branches of certain neurons were found in brain tissues of newborn rats but hardly in those of adult rats. Conclusion BAT2L protein is specifically expressed in cell body

membrane and prominence of neurons in brain of rats.

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