Effect of GasderminA3 gene mutation on β-catenin expression in mouse hair follicle in vivo

雷明星; 杨恬; 连小华; 杨力

您当前的位置：

首页 >

文章列表页 >

Effect of GasderminA3 gene mutation on β-catenin expression in mouse hair follicle in vivo

更新时间：2026-01-09

- Effect of GasderminA3 gene mutation on β-catenin expression in mouse hair follicle in vivo
- Journal of Army Medical University Vol. 32, Issue 5, Pages: 442-445(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R322.995;R329.28;R394.2
- Published：2010
- 稿件说明：
移动端阅览
雷明星,杨恬,连小华,杨力.GasderminA3基因突变对小鼠毛囊β-catenin表达的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(05):442-445.

　Lei Mingxing,Yang Tian,Lian Xiaohua,Yang Li.Effect of GasderminA3 gene mutation on β-catenin expression in mouse hair follicle in vivo[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(05):442-445.
雷明星,杨恬,连小华,杨力.GasderminA3基因突变对小鼠毛囊β-catenin表达的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(05):442-445. DOI：

　Lei Mingxing,Yang Tian,Lian Xiaohua,Yang Li.Effect of GasderminA3 gene mutation on β-catenin expression in mouse hair follicle in vivo[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(05):442-445. DOI：

摘要

目的探讨GasderminA3（GSDMa3）基因突变前后β-catenin在毛囊中表达的变化。方法采用免疫组化S-P法、RT-PCR、Western blot等方法，检测出生后11 d(毛囊生长期)、16 d(毛囊退化早期)、18 d(毛囊退化晚期)、24 d（毛囊静止期）等各个时相点的GSDMa3基因突变鼠和C57BL/6（B6）鼠背皮毛囊β-catenin的表达表化。结果 GSDMa3基因突变鼠和B6鼠β-catenin的表达均从11～24 d逐渐减弱，但GSDMa3基因突变鼠β-catenin的表达在各个时期均强于B6鼠。在生长期，β-catenin表达于内外根鞘和毛母质细胞中，在GSDMa3基因突变鼠的表达强于B6鼠；在退化期，β-catenin主要表达于外根鞘和毛母质细胞中，在突变鼠的表达更强于B6鼠；在静止期，β-catenin主要表达在突变鼠的外根鞘细胞中，而在B6鼠的毛囊中表达很少。结论 GSDMa3基因可能通过调节β-catenin的表达，影响毛囊的生长和发育。

Abstract

Objective To study the expression changes of β-catenin in the hair follicle before and after GasderminA3 gene mutation. Methods Using SP immunohistochemical staining

RT-PCR

Western blotting to detect the expression of β-catenin in the hair follicle in GSDMa3 mutant and C57BL/6 (B6) mice on postnatal 11 (anagen)

16 (early catagen)

18 (late catagen) and 24 d (telogen) respectively. Results The expression of β-catenin is gradually weakened from 11 d to 24 d in GSDMa3 mutation mice and B6 mice

but stronger expression was found in GSDMa3 mutation mice than in the B6 mice at different time points. In anagen

β-catenin was expressed in the inner and outer root sheath and hair matrix cells

with stronger expression in GSDMa3 mutant mice than in B6 mice. In catagen

β-catenin was mainly expressed in the outer root sheath and hair matrix cells

with more stronger expression in GSDMa3 mutant mice than in B6 mice. In telogen

β-catenin was expressed in the outer root sheath cells in the mutant mice while little in the hair follicle in B6 mice. Conclusion GSDMa3 gene affects the hair follicle growth and development

probably through regulating the expression of β-catenin.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression profile of Frizzled4 during hair follicle cycle

Expression pattern of gasdermin3 in synchronized mouse hair cycle

Mutations profiles of deafness genes in explosion-induced hearing loss caused by impulse noise

Naringin improves lipopolysaccharide-induced depression-like behaviors in mice

The role of cathepsin K in cardiac dysfunction in mice with alcoholic cardiomyopathy and its damage mechanism

Related Author

陈年

伍津津

邱伟明

唐辉

唐书谦

石家仲

杨恬

雷明星

Related Institution

No data

⁰