MRI signaling characteristics of ultra-small superparamagnetic iron oxide and GoldMag

逄鑫; 邹利光; 杨华; 张辉; 舒通胜; 张松

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MRI signaling characteristics of ultra-small superparamagnetic iron oxide and GoldMag

更新时间：2026-01-09

- MRI signaling characteristics of ultra-small superparamagnetic iron oxide and GoldMag
- Journal of Army Medical University Vol. 32, Issue 3, Pages: 229-232(2010)
- 作者机构：
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  CLC： R445.2;R811.1;R981.1
- Published：2010
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逄鑫,邹利光,杨华,张辉,舒通胜,张松.USPIO和GoldMag磁共振成像信号特点的实验研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(03):229-232.

　Pang Xin,Zou Liguang,Yang Hua,Zhang Hui,Shu Tongsheng,Zhang Song.MRI signaling characteristics of ultra-small superparamagnetic iron oxide and GoldMag[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(03):229-232.
逄鑫,邹利光,杨华,张辉,舒通胜,张松.USPIO和GoldMag磁共振成像信号特点的实验研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(03):229-232. DOI：

　Pang Xin,Zou Liguang,Yang Hua,Zhang Hui,Shu Tongsheng,Zhang Song.MRI signaling characteristics of ultra-small superparamagnetic iron oxide and GoldMag[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(03):229-232. DOI：

摘要

目的通过对不同浓度超小超顺磁性氧化铁（ultra-small superparamagnetic iron oxide，USPIO）和金磁微粒（GoldMagCoreshell

GoldMag）行不同序列MR成像，对比分析其信号特点，探讨合适的MRI检查方法。方法以磷酸盐缓冲液（PBS）为稀释剂将USPIO和GoldMag分别稀释为0.5～1 000 μg/ml的47个不同的浓度，以PBS液为对照，共获得48个浓度

行FSE T

WI、FSE T

WI和GRE T

*WI磁共振成像。观察不同浓度USPIO和GoldMag在3种序列中的信号强度变化规律，计算信号强度变化比率，绘制浓度信号强度曲线图。结果 GoldMag与USPIO的MRI信号变化规律基本一致，随浓度增加，FSE T

WI信号强度呈升高趋势，FSE T

WI信号强度略有下降，GRE T

*WI信号强度明显降低。不同成像序列两种对比剂信号强度比较，在FSE T

WI，浓度高于30 μg/ml时信号强度有显著性差异（P0.05）；在FSE T

WI，浓度为40～90 μg/ml时信号强度有显著性差异（P0.05）；在GRE T

*WI，两种对比剂信号强度无显著性差异（P0.05）。结论 GoldMag与USPIO常规MRI信号特点变化趋势相似，GoldMag是较理想的MRI分子影像学研究纳米粒对比剂，GRE T

*WI为USPIO和GoldMag的最佳成像序列。

Abstract

Objective To analyze the MRI signaling characteristics of ultra-small superparamagnetic iron oxide (USPIO) and GoldMag-Coreshell (GoldMag) at different concentrations and to study the appropriate MR imaging methods. Methods USPIO and GoldMag were diluted with phosphate-buffed solution (PBS) into 47 samples at the concentration

s of 0.5 μg/ml～1 000 μg/ml. MRI was performed at FSE T

FSE T

and GRE T

*WI. Rules of changes in signal intensity of GoldMag and USPIO at different concentrations were observed. The signal intensity change ratio was calculated and concentration-signal intensity curves were plotted. Results The MRI signal intensity of USPIO and GoldMag was almost identical. The MRI signal intensity increased at FSE T

WI with the increased concentration

decreased slightly at FSE T

WI and significantly at GRE T

*WI. A significant difference was found in the MRI signal intensity of the two contrast media (＞30 μg/ml

40-90 μg/ml）at FSE T

WI and FSE T

WI (P＜0.05) but not at GRE T

*WI (P＞0.05). Conclusion The MRI signal intensity of USPIO and GoldMag is almost identical. GoldMag is a rather ideal nanoparticle contrast agent for MRI molecular imaging

and GRE T

*WI is the best imaging sequence for USPIO and GoldMag.

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