Effect of stellate ganglion blocking on serum levels of Col, TNF-α, IL-1β and IL-6 in patients during cardiopulmonary bypass

张晓东; 杨天德; 李洪

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Effect of stellate ganglion blocking on serum levels of Col, TNF-α, IL-1β and IL-6 in patients during cardiopulmonary bypass

更新时间：2026-01-09

- Effect of stellate ganglion blocking on serum levels of Col, TNF-α, IL-1β and IL-6 in patients during cardiopulmonary bypass
- Journal of Army Medical University Vol. 32, Issue 10, Pages: 1028-1030(2010)
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  CLC： R392.3;R614.4;R654.1
- Published：2010
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张晓东,杨天德,李洪.星状神经节阻滞对体外循环术中皮质醇、TNF-α、IL-1β、IL-6的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1028-1030.

　Zhang Xiaodong,Yang Tiande,Li Hong.Effect of stellate ganglion blocking on serum levels of Col, TNF-α, IL-1β and IL-6 in patients during cardiopulmonary bypass[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1028-1030.
张晓东,杨天德,李洪.星状神经节阻滞对体外循环术中皮质醇、TNF-α、IL-1β、IL-6的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(10):1028-1030. DOI：

　Zhang Xiaodong,Yang Tiande,Li Hong.Effect of stellate ganglion blocking on serum levels of Col, TNF-α, IL-1β and IL-6 in patients during cardiopulmonary bypass[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(10):1028-1030. DOI：

摘要

目的探讨星状神经节阻滞后体外循环手术后患者炎症反应的影响。方法把我院心外科20例需进行二尖瓣置换的手术患者进行随机分组，分为对照组、星状神经节阻滞组（n=10）。对照组不予处理，星状神经节阻滞组予以1％利多卡因进行星状神经节阻滞。分别于术前20 min，麻醉后20 min，手术20 min，体外循环20 min，体外循环后20 min取血标本，检测皮质醇、IL-1β、IL-6、TNF-α的血浆浓度。结果皮质醇在体外循环后20 min时，星状神经节阻滞组（353.09±129.34）与对照组（486.84±152.20)有明显差异（P0.05）。IL-1β、IL-6、TNF-α都有逐渐上升的趋势；星状神经节阻滞组[IL-1β（0.15±0.06）、IL-6（293.50±54.41）、TNF-α（2.37±0.52）]在体外循环后20 min血浆浓度明显低于对照组[IL-1β （0.22±0.08）ng/ml，IL-6 (341.17±43.06) ng/ml， TNF-α(2.92±0.57）ng/ml，P0.05]。结论星状神经节阻滞可有效地减轻体外循环引起的炎症反应，其机制有待进一步探讨。

Abstract

Objective To study the effect of stellate ganglion blocking (SGB) during cardiopulmonary bypass (CPB) on inflammatory reaction. Methods Twenty patients undergoing mitral valve replacement were randomly allocated to 2 matched groups

control group and SGB group (n=10). The control group only received conventional anesthesia

while the SGB group was blocked with 1% lidocaine in addition before the operation for SBG. Blood glucose (BG)

Cortisol (Col)

IL-1β

IL-6 and TNF-α in the venous blood samples were detected in following 5 time points

20 min before anesthesia

20 min after anesthesia

20 min after operation

20 min afer the start of CPB and 20 min after the end of CPB. Results Col level of the control group (353.09±129.34 ng/ml) was significantly higher than that of the SGB group (486.84±152.20 ng/ml) in 20 min after the end of CPB (P0.05). Serum levels of IL-1β

IL-6 and TNF-α had a trend of increasing. However

the serum levels of IL-1β [(0.15±0.06) ng/ml

IL-6 (293.50±54.41) pg/ml

TNF-α (2.37±0.52) ng/ml] in the SGB group were lower than those of the control group [IL-1β (0.22±0.08) ng/ml

IL-6(341.17±43.06) pg/ml

and TNF-α (2.92±0.57) ng/ml] in 20 min after the end of CPB (P0.05). Conclusion SGB can relieve inflammatory reaction induced by CPB.

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