Effect of hypoxia simulating high altitude on sexual function in male rats

熊智勇; 葛亮; 季惠翔; 支轶; 吴晓军; 卢根生

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Effect of hypoxia simulating high altitude on sexual function in male rats

更新时间：2026-01-09

- Effect of hypoxia simulating high altitude on sexual function in male rats
- Journal of Army Medical University Vol. 32, Issue 7, Pages: 651-653(2010)
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  CLC： R698.02;R339.54;R-332
- Published：2010
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熊智勇,葛亮,季惠翔,支轶,吴晓军,卢根生.模拟高原缺氧对雄性大鼠性功能的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(07):651-653.

　Xiong Zhiyong,Ge Liang,Ji Huixiang,Zhi Yi,Wu Xiaojun,Lu Gensheng.Effect of hypoxia simulating high altitude on sexual function in male rats[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(07):651-653.
熊智勇,葛亮,季惠翔,支轶,吴晓军,卢根生.模拟高原缺氧对雄性大鼠性功能的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(07):651-653. DOI：

　Xiong Zhiyong,Ge Liang,Ji Huixiang,Zhi Yi,Wu Xiaojun,Lu Gensheng.Effect of hypoxia simulating high altitude on sexual function in male rats[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(07):651-653. DOI：

摘要

目的探讨模拟高原缺氧对雄性大鼠性功能的影响。方法将60只SD健康雄性大鼠随机分为平原对照组、缺氧2周组、缺氧4周组、缺氧6周组，每组15只。缺氧组大鼠置于模拟海拔4 500 m低压舱中，23 h/d，连续减压2、4、6周。观察各组大鼠性行为参数（乘骑、插入、射精的次数及潜伏期）和阿朴吗啡（apomorphine，APO）诱发阴茎勃起次数的变化；用ACCESS全自动免疫分析系统测定大鼠血清睾酮的含量；用化学比色法测定阴茎海绵体组织一氧化氮合酶(nitric oxide synthase，NOS)的活性；Masson染色观察阴茎海绵体组织结构变化。结果与平原对照组相比，各缺氧组大鼠的性行为参数（射精次数除外）受到抑制(P0.05)；APO诱发阴茎勃起的次数明显降低 (P0.05)；血清睾酮含量和阴茎组织中NOS活性均减低(P0.05)；Masson染色显示：大鼠阴茎海绵体平滑肌纤维减少，胶原纤维增多，窦状隙变小、变窄。且随着缺氧时间的延长，缺氧组大鼠的性行为逐渐受到抑制(P0.05)，血清睾酮含量及阴茎组织中NOS活性逐渐降低(P0.05)，阴茎海绵体组织结构纤维化程度加重。结论高原缺氧环境下成年雄性大鼠性功能受到抑制，且性功能受抑制程度与缺氧时间有一定的关系。

Abstract

Objective To study the relationship of hypoxia simulating high altitude and sexual function of rats. Methods Totally 60 adult male SD rats (3 months old) were randomly divided into control and hypoxia groups for 2

4 and 6 weeks (n=15 in each group). The rats of hypoxia groups were put into a hypobaric chamber simulating 4500-meter high altitude for 2

4 and 6 weeks (23 h/d)

and their sexual behaviors (times and latency of mount

intromission and ejaculation)

apomorphine-induced penile erections

content of testosterone in the serum

and nitric oxide synthase (NOS) and Masson staining in penis were examined. Results Compared with the control group

the sexual behaviors and the number of apomorphine-induced penile erections of hypoxia groups for 2

4 and 6 weeks were significantly inhibited (P0.05)

and testosterone in the serum and NOS activity in the penis of the experimental groups were reduced (P0.05). Masson staining showed that smooth fibers were decreased while collagen fibers were increased. Those changes were correlated with time elapse (P0.05). Conclusion The sexual function of rats is gradually restricted with increased time of hypoxia exposure in high altitude circumstance.

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