Effect of simulated high altitude hypoxia on matrix metalloproteinase-2 expression in serum of rats with chronic periodontitis

孔耀; 刘鲁川; 周霞; 刘福玉; 杨苏平; 张海元

您当前的位置：

首页 >

文章列表页 >

Effect of simulated high altitude hypoxia on matrix metalloproteinase-2 expression in serum of rats with chronic periodontitis

更新时间：2026-01-09

- Effect of simulated high altitude hypoxia on matrix metalloproteinase-2 expression in serum of rats with chronic periodontitis
- Journal of Army Medical University Vol. 32, Issue 4, Pages: 324-326(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R339.54;R446.112;R781.4
- Published：2010
- 稿件说明：
移动端阅览
孔耀,刘鲁川,周霞,刘福玉,杨苏平,张海元.模拟高原缺氧对慢性牙周炎大鼠血清中MMP-2表达的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(04):324-326.

　Kong Yao,Liu Luchuan,Zhou Xia,Liu Fuyu,Yang Suping,Zhang Haiyuan.Effect of simulated high altitude hypoxia on matrix metalloproteinase-2 expression in serum of rats with chronic periodontitis[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(04):324-326.
孔耀,刘鲁川,周霞,刘福玉,杨苏平,张海元.模拟高原缺氧对慢性牙周炎大鼠血清中MMP-2表达的影响[J].陆军军医大学学报(原第三军医大学学报),2010,32(04):324-326. DOI：

　Kong Yao,Liu Luchuan,Zhou Xia,Liu Fuyu,Yang Suping,Zhang Haiyuan.Effect of simulated high altitude hypoxia on matrix metalloproteinase-2 expression in serum of rats with chronic periodontitis[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(04):324-326. DOI：

摘要

目的研究常氧与缺氧条件下慢性牙周炎大鼠血清中基质金属蛋白酶2（matrix metalloproteinase-2

MMP-2）的表达变化，探讨MMP-2与高原牙周病的关系。方法模拟高原缺氧建立大鼠慢性牙周炎模型，采用ELISA法测定正常对照组、常氧牙周炎组、缺氧对照组、缺氧牙周炎组大鼠血清中MMP-2表达。结果正常对照组、常氧牙周炎组、缺氧对照组、缺氧牙周炎组血清中MMP-2浓度分别为(92.00±21.78)、(118.09±25.01)、(102.03±21.30)、(159.19±34.13) ng/ml，常氧牙周炎组与正常对照组、缺氧牙周炎组与缺氧对照组、缺氧对照组与正常对照组、缺氧牙周炎组与常氧牙周炎组比较均有统计学意义（P0.01）。其中缺氧牙周炎组血清中MMP-2浓度升高最为显著(P0.01)。结论缺氧上调血清中MMP-2的表达，进而促进大鼠牙周组织的破坏。

Abstract

Objective To study the change of matrix metalloproteinase-2 (MMP-2) expression in serum of rats with chronic periodontitis under normal oxygen or hypoxia conditions and the correlation between MMP-2 and high altitude periodontitis. Methods A chronic periodontitis model of rat was established by simulating high altitude hypoxia. Rats were divided into normal control (NC) group

normal oxygen periodontitis group (P

)

hypoxia control group（H）

and hypoxia periodontitis group (P

）. Expression of MMP-2 in serum of rats was detected by ELISA. Results The MMP-2 level in N

and P

groups was 92.00±21.78

118.09±25.01

102.03±21.30

and 159.19±34.13 ng/ml

respectively (P0.01). The serum MMP-2 level was significantly higher in P

group than in other groups. Conclusion Hypoxia up-regulates MMP-2 expression in serum and promotes destruction of periodontal tissue in rats

suggesting that MMP-2 participates in destruction of periodontal tissue during hypoxia periodontitis

which may be related with the recurrence and development of high altitude periodontal diseases.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Value of cardiac magnetic resonance tissue tracking imaging for assessment of early cardiac function in rats with left ventricular remodeling

Effect of dexmedetomidine on sevoflurane-induced endoplasmic reticulum stress in hippocampus of neonatal rats

Comparison of rat itch model induced by different pruritogens

Microarray analysis of the mechanism of liver injury induced by acute cadmium exposure in rats

Effects of Toll-like receptor 4 inhibitor on hypoxic-ischemic hippocampal neurons and dendritic spines in neonatal rats

Related Author

李亥辰

黎梅

黄睿珏

温小娟

张明星

郜发宝

邬颖华

白鹏祖

Related Institution

Department of Histology， Embryology and Neurobiology， West China School of Basic Medical Sciences and Forensic Medicine， Sichuan University

⁰