Acute heart failure following seawater immersion in dogs with open abdominal wound

胡媛琴; 王红勇; 高连如; 陈宇; 张宁坤; 曹毅; 杨晔

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Acute heart failure following seawater immersion in dogs with open abdominal wound

更新时间：2026-01-09

- Acute heart failure following seawater immersion in dogs with open abdominal wound
- Journal of Army Medical University Vol. 31, Issue 21, Pages: 2146-2149(2009)
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  CLC： R541.61;R656;R835.3
- Published：2009
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胡媛琴,王红勇,高连如,陈宇,张宁坤,曹毅,杨晔.腹部开放伤合并海水浸泡致犬急性心力衰竭的实验研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(21):2146-2149.

　HU Yuan-qin,WANG Hong-yong,GAO Lian-ru,CHEN Yu,ZHANG Ning-kun,CAO Yi,YANG Ye.Acute heart failure following seawater immersion in dogs with open abdominal wound[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(21):2146-2149.
胡媛琴,王红勇,高连如,陈宇,张宁坤,曹毅,杨晔.腹部开放伤合并海水浸泡致犬急性心力衰竭的实验研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(21):2146-2149. DOI：

　HU Yuan-qin,WANG Hong-yong,GAO Lian-ru,CHEN Yu,ZHANG Ning-kun,CAO Yi,YANG Ye.Acute heart failure following seawater immersion in dogs with open abdominal wound[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(21):2146-2149. DOI：

摘要

目的建立腹部开放伤合并海水浸泡犬急性心力衰竭模型，探讨海水浸泡对腹部开放伤犬急性心力衰竭的影响。方法成年杂种犬16只制备开放性腹部损伤动物模型，按随机数字表法分为海水浸泡组和对照组，每组8只。分别于致伤前、后，浸泡0.5、1、2 h及打捞后1、2 h监测2组犬的平均动脉压(mean artery pressure

MAP)、肺动脉嵌压（pulmonary artery wedge pressure

PAWP）、中心静脉压(central vein pressure

CVP)、心输出量(cardiac output

CO)，检测血浆K

、Na

、Cl

、血气、脑钠肽（brain natriuretic peptide

BNP）、TNF-α含量，测定致伤前、打捞后2 h心脏超声左心室收缩末容积（left ventricular end-systolic volume

LVESV）、左心室舒张末容积（left ventricular end-diastolic volume

LVEDV）、每博输出量（stroke volume

SV）、左心室射血分数（left ventricular ejection fraction

LVEF）值。结果浸泡组犬在浸泡后MAP、CVP、CO均下降，至2 h时，PAWP18 mmHg；LVESV、SV、LVEF均较对照组显著减低（P0.05），血浆K

、Na

、Cl

、BNP、TNF-α含量均较对照组显著升高（P0.05）；浸泡组犬在实验期间酸中毒程度逐渐加重，PH、HCO

进行性降低，与致伤前及对照组同时间点相比差异均有统计学意义（P0.05）。结论海水浸泡是导致腹部开放伤犬急性心力衰竭的重要因素。

Abstract

Objective To evaluate the effect of seawater immersion on acute heart failure in dogs with open abdominal wound and establish a relevant experimental model. Methods Sixteen health dogs were divided randomly into 2 groups

control group (n=8

) only having abdominal wound

and seawater immersion group (n=8) while abdominal wound was followed by seawater immersion. Mean artery pressure (MAP)

pulmonary artery wedge pressure (PAWP)

central vein pressure (CVP) and cardiac output (CO) were measured and blood samples were taken at different time intervals to determine K

－

blood gas

BNP and TNF-α levels. Doppler echocardiography was performed to measure the left ventricular end-systolic volume (LVESV)

left ventricular end-diastolic volume (LVEDV)

stroke volume (SV)

and left ventricular ejection fraction (LVEF) respectively. Results In seawater immersion group

MAP

CVP and CO were decreased after immersion. Compared with control group

LVESV

SV and LVEF were decreased and plasma levels of K

－

brain natriuretic peptide (BNP)

TNF-α were increased significantly in seawater immersion group (P0.05). In seawater immersion group

acidosis was aggravated gradually. pH value and HCO

were decreased significantly compared with control group (P0.05). Conclusion Seawater immersion is a significant factor of acute heart failure in dogs with open abdominal wound.

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