Association of lymphotoxin-α polymorphisms with myocardial infarction: a Meta-analysis

李亚; 王伦安; 贺勇

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Association of lymphotoxin-α polymorphisms with myocardial infarction: a Meta-analysis

更新时间：2026-01-09

- Association of lymphotoxin-α polymorphisms with myocardial infarction: a Meta-analysis
- Journal of Army Medical University Vol. 31, Issue 20, Pages: 2023-2026(2009)
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  CLC： R195.4;R394.3;R542.22
- Published：2009
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李亚,王伦安,贺勇.淋巴毒素α基因多态性与心肌梗死关系的Meta分析[J].陆军军医大学学报(原第三军医大学学报),2009,31(20):2023-2026.

　LI Ya,WANG Lun-an,HE Yong.Association of lymphotoxin-α polymorphisms with myocardial infarction: a Meta-analysis[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(20):2023-2026.
李亚,王伦安,贺勇.淋巴毒素α基因多态性与心肌梗死关系的Meta分析[J].陆军军医大学学报(原第三军医大学学报),2009,31(20):2023-2026. DOI：

　LI Ya,WANG Lun-an,HE Yong.Association of lymphotoxin-α polymorphisms with myocardial infarction: a Meta-analysis[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(20):2023-2026. DOI：

摘要

目的采用Meta分析系统评价淋巴毒素α（lymphotoxin-α，LTA）基因A252G、C804A多态性与心肌梗死（myocardial infarction，MI）的关系。方法检索PubMed和CNKI数据库（2002-2008年）中所有有关上述两种多态与MI相关性的随机病例对照研究，并用Revman4.2软件进行统计分析。结果共纳入9篇符合条件的文献，累计A252G多态研究例数：MI病例15 809例、对照9 566例；C804A多态研究人数：MI病例16 356例、对照9 966例。数据合并结果显示，病例与对照之间GG252 /（GA252+AA252）基因型的比值比（odds ratio，OR）为1.14，95%CI：0.94-1.38（P=0.19）；AA804 /（AG804+GG804）基因型的OR=1.06，95%CI：0.85-1.30（P=0.62）。另外，按东西方人群分组后的分析结果也与上述结果一致（P0.05）。结论 LTA基因GG252和AA804基因型不是MI的风险因子。受纳入文献数量的限制，本Meta分析结果尚有待更多高质量的大样本研究予以进一步证实。

Abstract

Objective To assess the association of A252G and C804A polymorphisms in the lymphotoxin-α (LTA) gene with myocardial infarction (MI) through Meta-analysis. Methods Case-control studies involved in the relationship between the 2 polymorphisms of LTA gene and MI were retrieved from PubMed and CNKI databases of 2002 to 2008.RevMan4.2 software was used for statistical analyses. Results Totally 9 eligible articles were selected in this study

including a total of 15 809 MI cases and 9 566 controls for the A252G polymorphism and a total of 16 356 MI subjects and 9 966 controls for the C804A polymorphism. The combined data revealed that the OR for MI was 1.14

95%CI: 0.94-1.38 (P=0.19) in GG252 genotype compared with (GA252+AA252) genotypes and the OR for MI was 1.06

95%CI: 0.85-1.30 (P=0.62) in AA804 genotype compared with (AG804+GG804) genotypes. Moreover

when subgroup analyses were carried out by race

these analyses were consistent with results mentioned above (P0.05). Conclusion The present data suggest that both GG252 and AA804 genotypes of the LTA gene are not the risk factors of MI. Further evaluations in adequately powered large studies are needed to confirm these findings.

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