Multivoxel 2D  <sup>1</sup>H-MRSI overlay anatomy imaging in grading malignancy of gliomas

方维东; 罗天友; 吕发金; 李咏梅; 吴景全

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Multivoxel 2D ¹H-MRSI overlay anatomy imaging in grading malignancy of gliomas

更新时间：2026-01-09

- Multivoxel 2D ¹H-MRSI overlay anatomy imaging in grading malignancy of gliomas
- Journal of Army Medical University Vol. 31, Issue 20, Pages: 2019-2022(2009)
- 作者机构：
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- DOI：
  CLC： R730.264;R730.44;R812
- Published：2009
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方维东,罗天友,吕发金,李咏梅,吴景全.多体素2D1H-MRSI-解剖叠加伪彩图在胶质瘤恶性程度分级中的应用[J].陆军军医大学学报(原第三军医大学学报),2009,31(20):2019-2022.

　FANG Wei-dong,LUO Tian-you,LU Fa-jin,LI Yong-mei,WU Jin-quan.Multivoxel 2D 1H-MRSI overlay anatomy imaging in grading malignancy of gliomas[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(20):2019-2022.
方维东,罗天友,吕发金,李咏梅,吴景全.多体素2D1H-MRSI-解剖叠加伪彩图在胶质瘤恶性程度分级中的应用[J].陆军军医大学学报(原第三军医大学学报),2009,31(20):2019-2022. DOI：

　FANG Wei-dong,LUO Tian-you,LU Fa-jin,LI Yong-mei,WU Jin-quan.Multivoxel 2D 1H-MRSI overlay anatomy imaging in grading malignancy of gliomas[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(20):2019-2022. DOI：

摘要

目的探讨多体素2D

H-MRSI（proton magnetic resonance Spectroscopy imaging ，

H-MRSI）-解剖叠加伪彩图在星形细胞胶质瘤恶性程度分级中的价值。方法对经手术切除病理证实的58例星形细胞胶质瘤的术前多体素2D

H-MRS 检查资料，利用机器自带的Functool (2) spectroscopy -2D Brain分析软件，获得

H-MRSI -解剖叠加伪彩图，包括Cho、Cr、NAA、Lip或Lac代谢-解剖叠加伪彩图以及Cho/NAA和Cho/Cr相对值分布-解剖叠加伪彩图，观测这些代谢物以及相对值在瘤体内的分布情况，依据上述相对值分布-解剖叠加伪彩图，在其相对值分布最大区分别测定（Cho/NAA）

max

和（Cho/Cr）

max

。结果上述代谢物以及相对值在瘤体内分布均呈现出异质性，其中Cho/NAA、Cho/Cr以及Cho在瘤体内呈非均匀性升高，相反NAA和Cr在瘤体内呈非均匀性减低，且这种异质性在恶性程度越高胶质瘤中越明显。低度恶性与高度恶性胶质瘤的（Cho/NAA）

max

和（Cho/Cr）

max

比值存在显著差异性（P0.01）；胶质瘤的（Cho/NAA）

max

、（Cho/Cr）

max

相对值与病理级别相关，尤以（Cho/NAA）

max

相对值反映胶质瘤级别较稳定（相关系数r

分别为0.923、0.802）。结论多体素2D H-MRSI-解剖叠加伪彩图能间接反映胶质瘤内部肿瘤组织的异质性，依据其所测量（Cho/NAA）

max

、（Cho/Cr）

max

在胶质瘤恶性程度评估中具有重要临床参考价值。

Abstract

Objective To explore the clinical value of multivoxel 2D Proton magnetic resonance spectroscopy imaging (

H-MRSI) overlay anatomy imaging in grading the malignancy of gliomas. Methods

Totally 58 patients with pathologically verified gliomas were examined before operations using conventional MRI and multi-voxel 2D

H-MRS. An attached software package Functool (2) spectroscopy-2D Brain was used to gain the H-MRSI overlay anatomy imaging

including the metabolic imaging+anatomy imaging (MIDI) color overplay map of Cho

NAA and Lip or Lac

and the distribution imaging+anatomy imaging (DIAI) color overlay map of Cho/NAA and Cho/Cr. The distributions of Cho

NAA

Lip or Lac

Cho/NAA and Cho/Cr in the lesions were observed

and the (Cho/NAA)

max

and (Cho/Cr)

max

were measured. Results Heterogeneous distribution of Cho

NAA

Lip or Lac

Cho/NAA and Cho/Cr were found in the tumor mass. Cho

and the ratios of Cho/NAA and Cho/Cr were increased heterogeneously

and NAA and Cr were decreased with heterogeneous display

especially in high-grade gliomas. A significant difference was found in the ratios of (Cho/NAA)

max

and (Cho/Cr)

max

between low- and high-grade gliomas (P0.01). There was significantly positive correlation between the ratios of (Cho/NAA)

max

and (Cho/Cr)

max

with the pathological grading of gliomas (r

=0.923

0.802 respectively). Conclusion Multivoxel 2D

H-MRSI overlay anatomy image indirectly reflects the heterogeneous of tumor tissues

and is helpful in the grading of gliomas by (Cho/NAA)

max

and (Cho/Cr)

max

through DIAI.

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Related Author

张伟国

方维东

罗天友

吕发金

李咏梅

史斌

吴景全

王博

Related Institution

Department of Pathology， Frist Affiliated Hospital， Army Medical University （Third Military Medical University）

Institute of Clinical Pathology， Key Laboratory of Tumor Immunopathology， Ministry of Education

Department of Radiology

Chongqing Clinical Research Centre of Imaging and Nuclear Medicine

Department of Pathology， Daping Hospital， Army Medical University

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Multivoxel 2D 1H-MRSI overlay anatomy imaging in grading malignancy of gliomas

DOI：

摘要

Abstract

关键词

Keywords

references

Multivoxel 2D ¹H-MRSI overlay anatomy imaging in grading malignancy of gliomas