Fibrosis of middle-small arteries and veins in early-stage uremic patients

冯菁; 彭侃夫; 吴雄飞

您当前的位置：

首页 >

文章列表页 >

Fibrosis of middle-small arteries and veins in early-stage uremic patients

更新时间：2026-01-09

- Fibrosis of middle-small arteries and veins in early-stage uremic patients
- Journal of Army Medical University Vol. 31, Issue 19, Pages: 1884-1886(2009)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R446;R543;R692.5
- Published：2009
- 稿件说明：
移动端阅览
冯菁,彭侃夫,吴雄飞.尿毒症患者早期小动静脉纤维化的变化[J].陆军军医大学学报(原第三军医大学学报),2009,31(19):1884-1886.

　FENG Jing,PENG Kan-fu,WU Xiong-fei.Fibrosis of middle-small arteries and veins in early-stage uremic patients[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(19):1884-1886.
冯菁,彭侃夫,吴雄飞.尿毒症患者早期小动静脉纤维化的变化[J].陆军军医大学学报(原第三军医大学学报),2009,31(19):1884-1886. DOI：

　FENG Jing,PENG Kan-fu,WU Xiong-fei.Fibrosis of middle-small arteries and veins in early-stage uremic patients[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(19):1884-1886. DOI：

摘要

目的探讨尿毒症患者早期小动静脉的纤维化改变。方法选择40例慢性肾脏病（chronic kidney disease， CKD）V期患者在行动静脉瘘手术时留取桡动脉及头静脉各0.5～1 cm。对照组选取4例行手部血管手术患者头静脉，用茜素红、HE及Masson染色三色法判断血管纤维化及钙化程度。同时采用免疫组织化学的方法检测α-平滑肌肌动蛋白（actinalpha

smoothmuscleaorta，α-SMA）、骨形成蛋白-2（bone morphology protein-2，BMP-2）、骨形成蛋白-7（bone morphology protein-7，BMP-7）表达。结果免疫组化α-SMA、BMP-2在CKD患者静脉的表达有明显的升高，与正常人群的静脉有显著性差异（P0.05），Masson染色、HE、茜素红染色提示尿毒症患者静脉改变以纤维化为主，而在尿毒症早期动脉改变不明显。结论尿毒症患者静脉的改变早于动脉的改变，而且以纤维化为主。提示静脉的改变同样可能与尿毒症患者心血管疾病密切相关。

Abstract

Objective To explore the pathological changes of the middle-small arteries and veins of uremic patients in early stage. Methods Forty patients with chronic kidney disease at Ⅴ stage were randomly subjected in our study. Radial artery and cephalic vein about 0.5 to 1 cm in length were obtained by arteriovenous fistula operations. Cephalic veins from 4 trauma patients were taken as control group. Immunohistochemisty with anti-α-SMA (smooth muscle actin-alpha)

BMP-2 (bone morphology protein-2) and BMP-7 (bone morphology protein-7) antibodies

alizarin Bordeaux staining

HE staining and Masson trichrome staining were carried out to investigate calcification and fibrosis. Results Compared with control group

the expressions of α-SMA and BMP-2 were up-regulated obviously. Masson trichrome staining indicated fibrosis in the vein from uremic patients. Conclusion Fibrosis may be one of the early pathologic changes in the vein from uremic patients

suggesting the venous alterations may be related to cardiovascular disease of uremic patients.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Risk factors for early hypocalcemia after total parathyroidectomy with autotransplantation in patients with uremic secondary hyperparathyroidism

Efficiency of continuous positive airway pressure treatment in uremia patients with acute left heart failure

Safety of ultrasound-guided deep vein catheterization in uremic patients with heart failure under unconventional body positions: report of 148 cases

Effect of Treg/Th17 cells dysfunction on expression of vascular calcification factor BMP-2 in uremia patients with dialysis

Effect of 1,25-(OH)₂D₃ and LPS on expression of vitamin D receptor in human monocytes incubated with sera from type 2 diabetes patients and diabetic nephropathy patients with uremia

Related Author

王尊松

王素霞

李洋

姜超云

廖剑雄

周永刚

杨秀林

吴明

Related Institution

No data

⁰