Pharmacokinetics of flurbiprofen orally disintegrating tablets in healthy rabbits

来小丹; 刘松青; 陈勇川; 代青; 贺红军; 谢林利

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Pharmacokinetics of flurbiprofen orally disintegrating tablets in healthy rabbits

更新时间：2026-01-09

- Pharmacokinetics of flurbiprofen orally disintegrating tablets in healthy rabbits
- Journal of Army Medical University Vol. 31, Issue 22, Pages: 2243-2245(2009)
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  CLC： R944.4;R969.1;R978.19
- Published：2009
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来小丹,刘松青,陈勇川,代青,贺红军,谢林利.氟比洛芬口崩片在健康家兔体内的药代动力学研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(22):2243-2245.

　LAI Xiao-dan,LIU Song-qing,CHEN Yong-chuan,DAI Qing,HE Hong-jun,XIE Lin-li.Pharmacokinetics of flurbiprofen orally disintegrating tablets in healthy rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(22):2243-2245.
来小丹,刘松青,陈勇川,代青,贺红军,谢林利.氟比洛芬口崩片在健康家兔体内的药代动力学研究[J].陆军军医大学学报(原第三军医大学学报),2009,31(22):2243-2245. DOI：

　LAI Xiao-dan,LIU Song-qing,CHEN Yong-chuan,DAI Qing,HE Hong-jun,XIE Lin-li.Pharmacokinetics of flurbiprofen orally disintegrating tablets in healthy rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2009,31(22):2243-2245. DOI：

摘要

目的研究氟比洛芬口崩片在兔体内的药代动力学特征。方法 6只受试兔随机分成2组：单剂量交叉口服氟比洛芬口崩片1片(50 mg/片)和普通片1片(50 mg/片)，于一定时间采集血样，用高效液相色谱法测定24 h内的血浆药物浓度。采用DAS2.0软件对有关参数进行方差分析。结果氟比洛芬口崩片和普通片T

1/2

(h)分别为（7.072±1.102）和（6.338±1.913），C

max

(μg/ml) 分别为（11.473±0.542）和（11.558±0.437），T

max

(h) 分别为（0.292±0.102）和（0.917±0.129），AUC(0-t) (μg/ml·h) 分别为（77.441±10.677）和（76.741±11.890），AUC(0-∞) (μg/ml·h) 分别为（84.836±12.588）和（83.305±16.980）。氟比洛芬口崩片平均相对生物利用度为102.7％。结论氟比洛芬口崩片与普通片具有生物学等效性。

Abstract

Objective To assess the pharmacokinetic profiles of flurbiprofen orally disintegrating tablets. Methods This study was carried out in 6 rabbits using a single-dose randomized two-way crossover design. The test group was given one tablet (50 mg) of flurbiprofen orally disintegrating tablets and the reference group was given one tablet (50 mg) of common flurbiprofen tablets. The drug concentrations in their plasma were assayed by HPLC. The pharmacokinetic parameters of the 2 tablets were calculated with the DAS 2.0 software. Results The major pharmacokinetic parameters of test and reference tabl

ets were as follows: T

1/2

(h) were 7.072±1.102 and 6.338±1.913，C

max

(μg/ml) were 11.473±0.542 and 11.558±0.437，T

max

(h) were 0.292±0.102 and 0.917±0.129，AUC(0-t) (μg/ml·h) were 77.441±10.677 and 76.741±11.890，AUC(0-∞) (μg/ml·h) were 84.836±12.588 and 83.305±16.980. The mean relative bioavailability of flurbiprofen orally disintegrating tablets vs reference was 102.7％. Conclusion Flurbiprofen orally disintegrating tablets are bioequivalent to the common flurbiprofen tablets.

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